当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2015年
24期
47-48
,共2页
社区获得性肺炎%PSI%氨基末端脑钠肽%高敏肌钙蛋白T
社區穫得性肺炎%PSI%氨基末耑腦鈉肽%高敏肌鈣蛋白T
사구획득성폐염%PSI%안기말단뇌납태%고민기개단백T
Community acquired pneumonia%PSI%N terminal B-type natriuretic peptide%High-sensitivity cardiac troponin T
目的：探讨氨基末端脑钠肽（NT-proBNP)和高敏肌钙蛋白T（cTnT-hs）对老年社区获得性肺炎患者严重程度及预后的预测价值。方法对临床诊断为肺炎的156例老年患者评估肺炎严重指数（PSI)，同时检测NT-proBNP和cTnT-hs。按照PSI分组，比较各组NT-proBNP和cTnT-hs水平，比较生存组与死亡组NT-proBNP和cTnT-hs水平，比较NT-proBNP和cTnT-hs双阳性组与NT-proBNP和cTnT-hs单阳性组间的病死率。结果各组NT-proBNP和cTnT-hs浓度随PSI分级而升高。死亡组患者中NT-proBNP浓度与存活组相比显著升高，差异有统计学意义（P<0.01)。NT-proBNP和cTnT-hs双阳性组与NT-proBNP和cTnT-hs单阳性组间病死率比较，差异具有统计学意义(P<O.01)。结论 NT-proBNP和cTnT-hs在评估老年社区获得性肺炎患者的病情严重程度及预后中具有重要作用，而联合检测血清NT-proBNP和cTnT-hs可更加有效地判断患者的预后。
目的：探討氨基末耑腦鈉肽（NT-proBNP)和高敏肌鈣蛋白T（cTnT-hs）對老年社區穫得性肺炎患者嚴重程度及預後的預測價值。方法對臨床診斷為肺炎的156例老年患者評估肺炎嚴重指數（PSI)，同時檢測NT-proBNP和cTnT-hs。按照PSI分組，比較各組NT-proBNP和cTnT-hs水平，比較生存組與死亡組NT-proBNP和cTnT-hs水平，比較NT-proBNP和cTnT-hs雙暘性組與NT-proBNP和cTnT-hs單暘性組間的病死率。結果各組NT-proBNP和cTnT-hs濃度隨PSI分級而升高。死亡組患者中NT-proBNP濃度與存活組相比顯著升高，差異有統計學意義（P<0.01)。NT-proBNP和cTnT-hs雙暘性組與NT-proBNP和cTnT-hs單暘性組間病死率比較，差異具有統計學意義(P<O.01)。結論 NT-proBNP和cTnT-hs在評估老年社區穫得性肺炎患者的病情嚴重程度及預後中具有重要作用，而聯閤檢測血清NT-proBNP和cTnT-hs可更加有效地判斷患者的預後。
목적：탐토안기말단뇌납태（NT-proBNP)화고민기개단백T（cTnT-hs）대노년사구획득성폐염환자엄중정도급예후적예측개치。방법대림상진단위폐염적156례노년환자평고폐염엄중지수（PSI)，동시검측NT-proBNP화cTnT-hs。안조PSI분조，비교각조NT-proBNP화cTnT-hs수평，비교생존조여사망조NT-proBNP화cTnT-hs수평，비교NT-proBNP화cTnT-hs쌍양성조여NT-proBNP화cTnT-hs단양성조간적병사솔。결과각조NT-proBNP화cTnT-hs농도수PSI분급이승고。사망조환자중NT-proBNP농도여존활조상비현저승고，차이유통계학의의（P<0.01)。NT-proBNP화cTnT-hs쌍양성조여NT-proBNP화cTnT-hs단양성조간병사솔비교，차이구유통계학의의(P<O.01)。결론 NT-proBNP화cTnT-hs재평고노년사구획득성폐염환자적병정엄중정도급예후중구유중요작용，이연합검측혈청NT-proBNP화cTnT-hs가경가유효지판단환자적예후。
Objective To evaluate the predictive value of combined measurement of N terminal B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (cTnT-hs) in elder community acquired pneumonia.Methods The blood levels of NT-proBNP and cTnT-hs in 156 patients with CAP were measured, the positive rates of cTnT-hs and NT-proBNP were also analyzed and compared between different groups. Results The blood levels of NT-proBNP and cTnT-hs increased with rising disease severity as classified by the PSI. NT-proBNP levels were signifi cantly higher in nonsurvivors compared to survivors (P<0.01). There was a signifi cant difference between the mortality in positive cTnT-hs alone and positive NT-proBNP alone group and both NT-proBNP and cTnT-hs positive group (P<0.01).Conclusion Either positive NT-proBNP or positive cTnT-hs plays an important role in evaluating the severity of diseases and predicting the prognosis in elder community acquired pneumonia. Combined measurement of NT-proBNP and cTnT-hs may help to assess prognosis more effective.
