CAJ | 학술논문

目的：观察单纯性肥胖儿童中脂肪肝的发生情况，以及血脂、转氨酶等指标的改变，并探究炎性因子在肥胖脂肪肝发生中的作用。方法：将121例单纯性肥胖儿童根据影像学检查结果分为脂肪肝组和非脂肪肝组，并抽取31例健康儿童为对照组。测量所有儿童的身高、体重、腰围、臀围，计算 BMI 值、腰臀比、腰围身高比。检测血脂，转氨酶及 hs‐CRP ，脂联素，TNF‐α的水平。结果：三组儿童的 BMI 、腰围、腰臀比均有显著性差异（ P ＜0．05），脂肪肝组及非脂肪肝组儿童腰围／身高比（WHtR）与对照组相比有显著性差异（ P ＜0．05），脂肪肝组及非脂肪肝组儿童 TG 及TCH 与对照组比较有显著性差异（P ＜0．05）；三组儿童的 AST 及 ALT 均有显著性差异（P ＜0．05）。结论：谷丙及谷草转氨酶在肥胖脂肪肝早期会显著升高，脂肪肝形成与炎症反应增强有关。
목적：관찰단순성비반인동중지방간적발생정황，이급혈지、전안매등지표적개변，병탐구염성인자재비반지방간발생중적작용。방법：장121례단순성비반인동근거영상학검사결과분위지방간조화비지방간조，병추취31례건강인동위대조조。측량소유인동적신고、체중、요위、둔위，계산 BMI 치、요둔비、요위신고비。검측혈지，전안매급 hs‐CRP ，지련소，TNF‐α적수평。결과：삼조인동적 BMI 、요위、요둔비균유현저성차이（ P ＜0．05），지방간조급비지방간조인동요위／신고비（WHtR）여대조조상비유현저성차이（ P ＜0．05），지방간조급비지방간조인동 TG 급TCH 여대조조비교유현저성차이（P ＜0．05）；삼조인동적 AST 급 ALT 균유현저성차이（P ＜0．05）。결론：곡병급곡초전안매재비반지방간조기회현저승고，지방간형성여염증반응증강유관。
Objective :To observe changes of blood lipids ,transaminase and other related parameters , and to investigate actions of inflammatory factors on the occurrence of nonalcoholic fatty liver in obese children . Methods :A total of 121 obese children and 31 healthycontrols were enrolled in this study .Obesity was defined as a body mass index exceeding the 95thpercentile for the patients'age and sex .Nonalcoholic fatty liver was diagnosed via ultrasonographic examin ‐ation .Obese children were divided into two groups ,fatty liver group(C group) and non‐fatty liver group(B group) ,31 healthy children as control group(A group) .The height ,weight ,BMI ,waistline , hipline ,waist‐to‐hip ratio and Waist to height ratio were measured and documented for every child .Blood lipids , transaminase ,hs‐CRP ,adiponectin and TNF‐α were also measured .Results : There are significant differences in BMI ,waistline and waist‐to‐hip ratio between any two groups(P< 0 .05) .Waist to height ratio ,TG and TCH was different significantly between B /A ,and C /A(P< 0 .05) .AST and ALT were also found different significantly be‐tween any two groups(P< 0 .05) ,and levels of transaminases increased gradually among A ,B and C groups .Con‐clusion :In this study ,levels of AST and ALT were found higher than controls in early phase of nonalcoholic fatty liver in obese children .Enhancement of inflammatory reaction was in relation with fatty liver .