CAJ | 학술논문

目的：分析停用头孢他啶前后对革兰阴性细菌耐药的变化。方法对2011年~2013年期间，我院对抗菌药物进行干预管理和监督，即停用头孢他啶，与未实行任何管理方式的2010年比较，观察医院大肠杆菌、铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌耐药产生情况。结果大肠埃希菌对头孢他啶耐药率由2010年82.99%降低至2013年27.34%，对铜绿假单胞菌耐药率由55.68%降低至23.29%，对肺炎克雷伯菌耐药率由81.25降低至43.29%，对鲍曼不动杆菌耐药率由84.87降低至57.14%，全部统计结果（P＜0.01），具有显著性差异。结论建立细菌耐药预警机制，采取合理干预监管措施停用细菌耐药率超过75%的抗菌药物，可在3年内降低其耐药率并恢复其敏感性。
목적：분석정용두포타정전후대혁란음성세균내약적변화。방법대2011년~2013년기간，아원대항균약물진행간예관리화감독，즉정용두포타정，여미실행임하관리방식적2010년비교，관찰의원대장간균、동록가단포균、폐염극뢰백균、포만불동간균내약산생정황。결과대장애희균대두포타정내약솔유2010년82.99%강저지2013년27.34%，대동록가단포균내약솔유55.68%강저지23.29%，대폐염극뢰백균내약솔유81.25강저지43.29%，대포만불동간균내약솔유84.87강저지57.14%，전부통계결과（P＜0.01），구유현저성차이。결론건립세균내약예경궤제，채취합리간예감관조시정용세균내약솔초과75%적항균약물，가재3년내강저기내약솔병회복기민감성。
Objective?To investigate on change of bacterial resistance before and after discontinuation of ceftazidine. Methods?Comparing bacterial resistance of Escherichia coli, Pseudomonas aeruginosa, klebsiella pneumonia and Acinetobacter baumannii from no intervention in 2010 to intervention management, supervise drugs resistance and discontinuation of ceftazidine between 2011 to 2013. Results?E.coli resisted rate to antibiotic Ceftazidine dramatically decreases from 82.99%to27.34%. As for P. aeruginosa , antibiotic resistant rate goes down signiifcantly from 55.68%to23.29%.And antibiotic resistant rate of klebsiella pneumonia reduces from 81.25%to43.29%. In addition, antibiotic resistant rate of Acinetobacter baumannii drops from 84.87%to 57.14%. There is signiifcant difference of drug resistance between years (P<0.01). Conclusion?Estabished bacterial resistant alarming mechanism and take comprehensive measures to discontinue of antibiotics with drug resistance over 75%can signiifcantly reduce drug resistance rates and restore drug sensitivities within 3 years.