中国执业药师
中國執業藥師
중국집업약사
CHINA LICENSED PHARMACIST
2015年
9期
40-45
,共6页
药师%药学服务%Meta分析%糖尿病%依从性
藥師%藥學服務%Meta分析%糖尿病%依從性
약사%약학복무%Meta분석%당뇨병%의종성
Pharmacist%Pharmaceutical Care%Meta-analysis%Diabetes Mellitus%Adherence
目的:系统评价国内由药师开展的药学干预对糖尿病患者用药依从性和血糖控制的影响。方法:计算机检索Pubmed(1993-2013)、中国期刊全文数据库(CNKI ,1993-2013)、维普数据库(VIP ,1993-2013)和中国生物医学文献数据库光盘版(CBMdisc ,1993-2013),按纳入、排除标准收集相关文献,对其进行资料提取和方法学质量评价,使用Revman 5.2软件对资料进行Meta分析。结果:共纳入13个随机对照研究,均为中文文献,方法学质量不高。 Meta 分析显示:药师开展的药学干预对糖尿病患者的用药依从性[ RR =1.83,95%CI (1.32,2.53),P =0.0002]、空腹血糖[SMD =-2.82,95%CI(-4.49,-1.14),P =0.001]、糖化血红蛋白[SMD =-1.58,95%CI(-2.58,-0.57),P =0.002]的影响有统计学意义。对餐后2小时血糖[SMD =-3.12,95%CI (-6.69,0.45),P =0.09]、药品不良事件发生率[RR =0.45,95%CI(0.17,1.14),P =0.09]的影响无统计学意义。结论:药师开展的药学干预能提高糖尿病患者的用药依从性,改善血糖控制。但仍需要开展大规模设计良好的随机对照研究和更长时间的随访来进一步验证。
目的:繫統評價國內由藥師開展的藥學榦預對糖尿病患者用藥依從性和血糖控製的影響。方法:計算機檢索Pubmed(1993-2013)、中國期刊全文數據庫(CNKI ,1993-2013)、維普數據庫(VIP ,1993-2013)和中國生物醫學文獻數據庫光盤版(CBMdisc ,1993-2013),按納入、排除標準收集相關文獻,對其進行資料提取和方法學質量評價,使用Revman 5.2軟件對資料進行Meta分析。結果:共納入13箇隨機對照研究,均為中文文獻,方法學質量不高。 Meta 分析顯示:藥師開展的藥學榦預對糖尿病患者的用藥依從性[ RR =1.83,95%CI (1.32,2.53),P =0.0002]、空腹血糖[SMD =-2.82,95%CI(-4.49,-1.14),P =0.001]、糖化血紅蛋白[SMD =-1.58,95%CI(-2.58,-0.57),P =0.002]的影響有統計學意義。對餐後2小時血糖[SMD =-3.12,95%CI (-6.69,0.45),P =0.09]、藥品不良事件髮生率[RR =0.45,95%CI(0.17,1.14),P =0.09]的影響無統計學意義。結論:藥師開展的藥學榦預能提高糖尿病患者的用藥依從性,改善血糖控製。但仍需要開展大規模設計良好的隨機對照研究和更長時間的隨訪來進一步驗證。
목적:계통평개국내유약사개전적약학간예대당뇨병환자용약의종성화혈당공제적영향。방법:계산궤검색Pubmed(1993-2013)、중국기간전문수거고(CNKI ,1993-2013)、유보수거고(VIP ,1993-2013)화중국생물의학문헌수거고광반판(CBMdisc ,1993-2013),안납입、배제표준수집상관문헌,대기진행자료제취화방법학질량평개,사용Revman 5.2연건대자료진행Meta분석。결과:공납입13개수궤대조연구,균위중문문헌,방법학질량불고。 Meta 분석현시:약사개전적약학간예대당뇨병환자적용약의종성[ RR =1.83,95%CI (1.32,2.53),P =0.0002]、공복혈당[SMD =-2.82,95%CI(-4.49,-1.14),P =0.001]、당화혈홍단백[SMD =-1.58,95%CI(-2.58,-0.57),P =0.002]적영향유통계학의의。대찬후2소시혈당[SMD =-3.12,95%CI (-6.69,0.45),P =0.09]、약품불량사건발생솔[RR =0.45,95%CI(0.17,1.14),P =0.09]적영향무통계학의의。결론:약사개전적약학간예능제고당뇨병환자적용약의종성,개선혈당공제。단잉수요개전대규모설계량호적수궤대조연구화경장시간적수방래진일보험증。
Objective: To evaluate the effect of pharmacist intervention on the medication compliance and blood glucose control of patients with diabetes in China . Methods: A computer-based retrieval was conducted of Pubmed ( 1993 - 2013 ) , CNKI ( 1993 - 2013 ) , VIP ( 1993 - 2013 ) and CBMdisc ( 1993 - 2013 ) for collecting the relevant data according to predefined inclusion and exclusion criteria and then studies were identified and their quality was evaluated . The meta-analysis was performed using Revman 5 . 2 software . Results: Thirteen randomized controlled trials ( RCTs ) were included which were published in Chinese . The results of meta-analysis showed there were significant differences between pharmacist intervention group and control group in the medication compliance of patients with diabetes mellitus [ RR = 1 . 83 , 95%CI ( 1 . 32 , 2 . 53 ) , P = 0 . 000 2 ] , FPG [ SMD = -2 . 82 , 95%CI (-4.49,-1.14), P = 0.001], and HbA1c [SMD = -1.58,95%CI (-2.58,-0.57), P = 0.002]. There were no significant differences in 2hPG [SMD = -3.12,95%CI (-6.69,0.45), P = 0.09] and incidence rate of adverse events [ RR = 0 . 45 , 95%CI ( 0 . 17 , 1 . 14 ) , P = 0 . 09 ] . Conclusion: Pharmacist intervention can improve the medication adherence and blood glucose control of the patients with diabetes . However , it is still necessary to carry out well-designed large scale RCTs and longer follow-up studies for the further confirmation .