军事医学
軍事醫學
군사의학
BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES
2015年
8期
621-625
,共5页
肺疾病,慢性阻塞性%急性加重%低分子肝素%Meta分析%系统评估%随机对照试验
肺疾病,慢性阻塞性%急性加重%低分子肝素%Meta分析%繫統評估%隨機對照試驗
폐질병,만성조새성%급성가중%저분자간소%Meta분석%계통평고%수궤대조시험
chronic obstructive pulmonary disease%acute exacerbation%low molecular weight heparin%meta-analysis%system assessment%randomized control trial
目的：系统评价低分子肝素（LMWH）治疗慢性阻塞性肺疾病急性加重（AECOPD）的疗效。方法计算机检索文献，查找采用LMWH＋常规治疗与单纯常规治疗比较AECOPD疗效的随机对照试验。按照纳入排除标准筛查文献，提取资料，进行质量评价，采用RevMan 5．2软件进行Meta分析。结果共纳入12个随机对照试验（RCT），共计879例患者。 Meta分析结果显示：①与对照组相比，LMWH可改善AECOPD患者的动脉血氧分压、二氧化碳分压。②LMWH治疗组对于患者肺功能FEV1和红细胞压积的改善，与对照组差异无统计学意义。结论与对照组相比， LMWH治疗组不能改善AECOPD患者FEV1和红细胞压积指标，但能有效改善动脉血氧分压及二氧化碳分压。
目的：繫統評價低分子肝素（LMWH）治療慢性阻塞性肺疾病急性加重（AECOPD）的療效。方法計算機檢索文獻，查找採用LMWH＋常規治療與單純常規治療比較AECOPD療效的隨機對照試驗。按照納入排除標準篩查文獻，提取資料，進行質量評價，採用RevMan 5．2軟件進行Meta分析。結果共納入12箇隨機對照試驗（RCT），共計879例患者。 Meta分析結果顯示：①與對照組相比，LMWH可改善AECOPD患者的動脈血氧分壓、二氧化碳分壓。②LMWH治療組對于患者肺功能FEV1和紅細胞壓積的改善，與對照組差異無統計學意義。結論與對照組相比， LMWH治療組不能改善AECOPD患者FEV1和紅細胞壓積指標，但能有效改善動脈血氧分壓及二氧化碳分壓。
목적：계통평개저분자간소（LMWH）치료만성조새성폐질병급성가중（AECOPD）적료효。방법계산궤검색문헌，사조채용LMWH＋상규치료여단순상규치료비교AECOPD료효적수궤대조시험。안조납입배제표준사사문헌，제취자료，진행질량평개，채용RevMan 5．2연건진행Meta분석。결과공납입12개수궤대조시험（RCT），공계879례환자。 Meta분석결과현시：①여대조조상비，LMWH가개선AECOPD환자적동맥혈양분압、이양화탄분압。②LMWH치료조대우환자폐공능FEV1화홍세포압적적개선，여대조조차이무통계학의의。결론여대조조상비， LMWH치료조불능개선AECOPD환자FEV1화홍세포압적지표，단능유효개선동맥혈양분압급이양화탄분압。
Objective To estimate the effect of low molecular weight heparin (LMWH) combined with conventional treatment on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Literature on randomized control trials( RCTs) with AECOPD treated by LMWH combined with conventional methods was collected in PubMed.The studies were selected according to inclusive and exclusive criteria.The data were extracted,the quality was assessed, and meta-analysis was conducted with RevMan 5.2 software.Results There were twelve RCTs including 879 patients with AECOPD in the current study.The results of meta-analysis showed that:①LMWH could obviously improve PaO2 and PaCO2 of patients with AECOPD as compared with the control group.②There was no statistically significant difference between the LMWH-treated group and control group in the improvement of FEV1 or hematocrit.Conclusion LMWH can significantly improve arterial blood gas analysis in AECOPD, but does not improve FEV1 or hematocrit.
