中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2015年
7期
119-121
,共3页
鼻咽癌%同步放化疗%疗效%生存率
鼻嚥癌%同步放化療%療效%生存率
비인암%동보방화료%료효%생존솔
Nasopharyngeal carcinoma%Concurrent chemoradiotherapy%Curative effect%Survival rate
目的：探讨同步放化疗治疗晚期鼻咽癌的临床效果。方法选择本院放疗科和肿瘤内科2007年8月至2009年8月收治的晚期鼻咽癌患者200例为研究对象，随机分为研究组与对照组，每组各100例。对照组患者给予常规分次放疗，研究组患者给予常规分次放疗同步顺铂（DDP）＋5-氟尿嘧啶（5-FU）方案化疗，比较两组患者近期疗效、放疗局部及全身不良反应发生情况及近/远期生存率。结果研究组患者近期临床有效率为96.0%（96/100），显著高于对照组[87.0%（87/100）]（P＜0.05）。两组患者颈部皮肤损害、口腔黏膜损害及鼻腔黏膜损害发生等级、白细胞减少及血小板减少发生率比较差异均无显著性（P＞0.05）。研究组患者治疗后1、3、5年生存率均高于对照组（P＜0.05）。结论晚期鼻咽癌患者同步放化疗，能够改善临床效果及患者预后，延长生存期，且具有较高的安全性，值得临床推广应用。
目的：探討同步放化療治療晚期鼻嚥癌的臨床效果。方法選擇本院放療科和腫瘤內科2007年8月至2009年8月收治的晚期鼻嚥癌患者200例為研究對象，隨機分為研究組與對照組，每組各100例。對照組患者給予常規分次放療，研究組患者給予常規分次放療同步順鉑（DDP）＋5-氟尿嘧啶（5-FU）方案化療，比較兩組患者近期療效、放療跼部及全身不良反應髮生情況及近/遠期生存率。結果研究組患者近期臨床有效率為96.0%（96/100），顯著高于對照組[87.0%（87/100）]（P＜0.05）。兩組患者頸部皮膚損害、口腔黏膜損害及鼻腔黏膜損害髮生等級、白細胞減少及血小闆減少髮生率比較差異均無顯著性（P＞0.05）。研究組患者治療後1、3、5年生存率均高于對照組（P＜0.05）。結論晚期鼻嚥癌患者同步放化療，能夠改善臨床效果及患者預後，延長生存期，且具有較高的安全性，值得臨床推廣應用。
목적：탐토동보방화료치료만기비인암적림상효과。방법선택본원방료과화종류내과2007년8월지2009년8월수치적만기비인암환자200례위연구대상，수궤분위연구조여대조조，매조각100례。대조조환자급여상규분차방료，연구조환자급여상규분차방료동보순박（DDP）＋5-불뇨밀정（5-FU）방안화료，비교량조환자근기료효、방료국부급전신불량반응발생정황급근/원기생존솔。결과연구조환자근기림상유효솔위96.0%（96/100），현저고우대조조[87.0%（87/100）]（P＜0.05）。량조환자경부피부손해、구강점막손해급비강점막손해발생등급、백세포감소급혈소판감소발생솔비교차이균무현저성（P＞0.05）。연구조환자치료후1、3、5년생존솔균고우대조조（P＜0.05）。결론만기비인암환자동보방화료，능구개선림상효과급환자예후，연장생존기，차구유교고적안전성，치득림상추엄응용。
ObjectiveTo investigate the clinical curative effect of concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma.Method200 patients with advanced nasopharyngeal carcinoma treated in our hospital from August 2007 to August 2009 were selected as the research objects, were randomly divided into study group and control group, 100 cases in each group. Control group patients received conventional fractionated radiotherapy, study group patients received conventional fractionated radiotherapy plus DDP+ 5-FU regimen chemotherapy. Short-term curative effect, radiation therapy, local and systemic adverse reactions and short-term, long-term survival rate of the two groups were compared.ResultShort-term curative effect rate was 96.0% (96/100) in study group, signiifcantly higher than control group [87.0% (87/100)] (P<0.05). The differences of the two groups of patients with neck skin damage, the damage of the oral mucosa and nasal mucosa damage levels, leukocytopenia and thrombocytopenia were not signiifcant (P>0.05). After treatment, 1, 3, 5 year survival rates of study group were higher than control group (P<0.05).ConclusionFor advanced nasopharyngeal carcinoma concurrent chemoradiotherapy can improve the clinical effect and prognosis of patients, prolong the survival period, and has high safety, worthy of clinical application.
