CAJ | 학술논문

目的：探究脑梗死患者血尿酸水平与颈动脉粥样硬化的相关性。方法选取2014年1月到2014年12月期间本院接收治疗的脑梗死患者300例。测定患者的血脂水平和血尿酸水平。使用超声检查检测患者是否有颈动脉斑块，将300例患者分为无斑块组和斑块组，并采用多因素logistic对影响斑块发生的因素进行回归分析。根据斑块的性质，将斑块组患者分为不稳定斑块组和稳定斑块组，对比各组间血尿酸的水平差异。结果无斑块组有137例，斑块组163例，比较两组患者的性别、年龄、总胆固醇、肥胖发生率和血尿酸水平，差异有显著性(P<0.05)。多因素logistic回归分析显示，年龄、性别、血尿酸、肥胖与颈动脉粥样硬化斑块有回归关系。稳定斑块组有88例患者，不稳定斑块组有75例。稳定斑块组、不稳定斑块组、无斑块组的血尿酸水平比较，差异有显著性(P<0.05)。无斑块组和不稳定斑块组的血尿酸相比较，差异有显著性(P<0.05)。结论脑梗死患者的血尿酸水平升高与颈动脉粥样硬化的发生有密切的关系，且与不稳定斑块的关系最密切。高龄、男性、总胆固醇、肥胖和尿酸水平升高是造成颈动脉粥样硬化斑块的危险因素。
목적：탐구뇌경사환자혈뇨산수평여경동맥죽양경화적상관성。방법선취2014년1월도2014년12월기간본원접수치료적뇌경사환자300례。측정환자적혈지수평화혈뇨산수평。사용초성검사검측환자시부유경동맥반괴，장300례환자분위무반괴조화반괴조，병채용다인소logistic대영향반괴발생적인소진행회귀분석。근거반괴적성질，장반괴조환자분위불은정반괴조화은정반괴조，대비각조간혈뇨산적수평차이。결과무반괴조유137례，반괴조163례，비교량조환자적성별、년령、총담고순、비반발생솔화혈뇨산수평，차이유현저성(P<0.05)。다인소logistic회귀분석현시，년령、성별、혈뇨산、비반여경동맥죽양경화반괴유회귀관계。은정반괴조유88례환자，불은정반괴조유75례。은정반괴조、불은정반괴조、무반괴조적혈뇨산수평비교，차이유현저성(P<0.05)。무반괴조화불은정반괴조적혈뇨산상비교，차이유현저성(P<0.05)。결론뇌경사환자적혈뇨산수평승고여경동맥죽양경화적발생유밀절적관계，차여불은정반괴적관계최밀절。고령、남성、총담고순、비반화뇨산수평승고시조성경동맥죽양경화반괴적위험인소。
Objective To explore the correlation between serum uric acid levels and carotid atherosclerosis in patients with cerebral infarction. Method 300 patients with cerebral infarction were selected from our hospital to receive treatment during January 2014 to December 2014. 300 patients blood lipid levels and blood uric acid levels were measured. Ultrasound was used to detect whether patients have carotid plaques, 300 patients were divided into with-out plaque group and plaque group, and the factors affecting plaque was analyzed by multivariate logistic regression. Depending on the nature of plaque, the plaque group was divided into unstable plaque group and stable plaques, and the differences among the groups in blood levels of uric acid were compared. Result There was a statistically significant difference between no plaque group 137 cases and plaque group 163 cases who were compared with gen-der, age, total cholesterol(TC), the incidence of obesity and blood uric acid levels (P<0. 05). It showed that age, sex, serum uric acid, obesity and carotid atherosclerosis plaque had a regression relationship which analyzed by logistic regression. There were 88 patients in the stable plaque group and 75 cases in the unstable plaque group. There was a significant difference in the level of serum uric acid among stable plaque group, unstable plaque group and non-plaque group (P<0. 05). There was a significant difference in the serum uric acid between the non-plaque group and the unstable plaque group (P<0. 05). Conclusion The rise of serum uric acid level in patients with cere-bral infarction is closely related to the occurrence of carotid atherosclerosis and unstable plaque is the most closely related. Age, male, total cholesterol, obesity and uric acid levels are the risk factors of carotid atherosclerosis plaque.