CAJ | 학술논문

目的：分析单相抑郁发作患者的情感气质类型与抑郁发作双极性的关系。方法本研究为横断面研究，入组36例治疗12周的单相抑郁症患者，采集患者的服药情况和评估治疗12周时的临床治愈率。根据Akiskal的软双相谱系理论，运用气质自评量表，将伴有旺盛气质和循环气质的单相抑郁发作归为软双相谱。结果36例患者分为10例（27．8％）软双相谱系患者（9例为临床治愈）和26例严格的单相抑郁患者（18例为临床治愈）。软双相谱系患者的年龄明显低于严格的单相抑郁患者。两组在气质类型，循环气质（P＜0．01）、焦虑气质（P＜0．01）、易激惹气质（P＜0．01）、抑郁气质（P＜0．05）具有明显差异。在10例软双相谱系患者中，心境稳定剂锂盐治疗组的临床治愈率明显高于非锂盐治疗组（P ＜0．01）。结论情感气质或许能预测抑郁发作的双极性，心境稳定剂能够改善软双相谱系患者的临床症状，为软双相谱系概念提供了支持性证据。
목적：분석단상억욱발작환자적정감기질류형여억욱발작쌍겁성적관계。방법본연구위횡단면연구，입조36례치료12주적단상억욱증환자，채집환자적복약정황화평고치료12주시적림상치유솔。근거Akiskal적연쌍상보계이론，운용기질자평량표，장반유왕성기질화순배기질적단상억욱발작귀위연쌍상보。결과36례환자분위10례（27．8％）연쌍상보계환자（9례위림상치유）화26례엄격적단상억욱환자（18례위림상치유）。연쌍상보계환자적년령명현저우엄격적단상억욱환자。량조재기질류형，순배기질（P＜0．01）、초필기질（P＜0．01）、역격야기질（P＜0．01）、억욱기질（P＜0．05）구유명현차이。재10례연쌍상보계환자중，심경은정제리염치료조적림상치유솔명현고우비리염치료조（P ＜0．01）。결론정감기질혹허능예측억욱발작적쌍겁성，심경은정제능구개선연쌍상보계환자적림상증상，위연쌍상보계개념제공료지지성증거。
Objective To explore the relationship between affective temperament and bipolarity in depression episode .Methods This study was a cross-sectional study .Thirty -six unipolar depression patients treated 12 weeks were included ,the medication compliance and the clinical cure rate were col‐lected .The unipolar depression with exuberant and cycle temperament was classified as soft bipolar spec‐trum according with the soft bipolar spectrum theory and the temperament evaluation scale . Results There were 10(27 .8% ) soft bipolar spectrum patients (9 patients were clinically cured) and 26 rigorous unipolar depression(18 patients were clinically cured) .Patients with bipolar spectrum were sig‐nificantly younger than patients with unipolar depression .There were significantly different between bi‐polar spectrum with unipolar depression in affective temperament(i .e .cycle ,anxiety ,irritability and de‐pression temperament) (P < 0 .01) .Bipolar spectrum patients with lithium treatment and had signifi‐cantly higher remission rates than patients without lithium treatment (P< 0 .01) .Conclusions The af‐fective temperament may predict the bipolarity in depression episode ,mood stabilizers can improve clini‐cal symptoms in patients with soft bipolar spectrum ,which provide supporting evidence for the concept of soft bipolar spectrum .