神经疾病与精神卫生
神經疾病與精神衛生
신경질병여정신위생
NERVOUS DISEASES AND MENTAL HYGIENE
2015年
4期
368-371
,共4页
刘玉娇%周洪海%王承敏%胡建
劉玉嬌%週洪海%王承敏%鬍建
류옥교%주홍해%왕승민%호건
抑郁症%甲状腺激素%甲状腺抗体%认知
抑鬱癥%甲狀腺激素%甲狀腺抗體%認知
억욱증%갑상선격소%갑상선항체%인지
Depression%Thyroid hormones%Thyroid antibodies%Perceive
目的：探讨抑郁症患者甲状腺激素（T Hs）及抗体与抑郁症严重程度及认知功能的关系。方法采集60例单相抑郁症患者与58名健康对照组静脉血，测定TSH、FT4、FT3、Anti－TPO、Anti－TG水平，并行HAMD－24、HAMA、威斯康星卡片分类测验（WCST）进行抑郁、焦虑、认知功能评定。结果抑郁症组血清FT4水平较对照组高，TSH水平较对照组低，差异均有统计学意义（P ＜0．01）；抑郁症组认知功能明显均低于对照组（P ＜0．05）。TSH与抑郁症严重程度、与阻滞、绝望因子呈负相关（ r分别为－0．320，－0．345，－0．290；P ＜0．05），与认知功能中的总正确数、完成分类数呈正相关，与总错误数呈负相关（ r分别为0．396，0．476，－0．325；P ＜0．05）；F T 4与焦虑躯体化、精神性焦虑呈正相关（r分别为0．381，0．320；P＜0．05）；FT3、Anti－TPO与日夜变化呈负相关（r分别为－0．302，－0．385；P＜0．05）。结论抑郁症患者存在甲状腺功能的紊乱，甲状腺功能的紊乱可能与抑郁症的严重程度以及焦虑躯体化、阻滞、绝望、日夜变化等症状相关，甲状腺功能紊乱会导致认知功能的异常。
目的：探討抑鬱癥患者甲狀腺激素（T Hs）及抗體與抑鬱癥嚴重程度及認知功能的關繫。方法採集60例單相抑鬱癥患者與58名健康對照組靜脈血，測定TSH、FT4、FT3、Anti－TPO、Anti－TG水平，併行HAMD－24、HAMA、威斯康星卡片分類測驗（WCST）進行抑鬱、焦慮、認知功能評定。結果抑鬱癥組血清FT4水平較對照組高，TSH水平較對照組低，差異均有統計學意義（P ＜0．01）；抑鬱癥組認知功能明顯均低于對照組（P ＜0．05）。TSH與抑鬱癥嚴重程度、與阻滯、絕望因子呈負相關（ r分彆為－0．320，－0．345，－0．290；P ＜0．05），與認知功能中的總正確數、完成分類數呈正相關，與總錯誤數呈負相關（ r分彆為0．396，0．476，－0．325；P ＜0．05）；F T 4與焦慮軀體化、精神性焦慮呈正相關（r分彆為0．381，0．320；P＜0．05）；FT3、Anti－TPO與日夜變化呈負相關（r分彆為－0．302，－0．385；P＜0．05）。結論抑鬱癥患者存在甲狀腺功能的紊亂，甲狀腺功能的紊亂可能與抑鬱癥的嚴重程度以及焦慮軀體化、阻滯、絕望、日夜變化等癥狀相關，甲狀腺功能紊亂會導緻認知功能的異常。
목적：탐토억욱증환자갑상선격소（T Hs）급항체여억욱증엄중정도급인지공능적관계。방법채집60례단상억욱증환자여58명건강대조조정맥혈，측정TSH、FT4、FT3、Anti－TPO、Anti－TG수평，병행HAMD－24、HAMA、위사강성잡편분류측험（WCST）진행억욱、초필、인지공능평정。결과억욱증조혈청FT4수평교대조조고，TSH수평교대조조저，차이균유통계학의의（P ＜0．01）；억욱증조인지공능명현균저우대조조（P ＜0．05）。TSH여억욱증엄중정도、여조체、절망인자정부상관（ r분별위－0．320，－0．345，－0．290；P ＜0．05），여인지공능중적총정학수、완성분류수정정상관，여총착오수정부상관（ r분별위0．396，0．476，－0．325；P ＜0．05）；F T 4여초필구체화、정신성초필정정상관（r분별위0．381，0．320；P＜0．05）；FT3、Anti－TPO여일야변화정부상관（r분별위－0．302，－0．385；P＜0．05）。결론억욱증환자존재갑상선공능적문란，갑상선공능적문란가능여억욱증적엄중정도이급초필구체화、조체、절망、일야변화등증상상관，갑상선공능문란회도치인지공능적이상。
Objective To explore the relationship between the thyroid hormone and antibody and severity and cognitive function in patients with depression .Methods Collected venous blood of 60 cases in single-phase depression patients and 58 healthy controls ,measuring the level of TSH ,FT4 ,FT3 , Anti-TPO ,Anti - TG ,assessing depression ,anxiety and cognitive function through HAMD -24 , HAMA and Wisconsin Card Sorting Test .Results Depression patients presented significantly higher se‐rum level of FT4 and lower serum level of TSH than the healthy control group ,the differences were sta‐tistically significant (P< 0 .01);The cognitive function of depression group was significantly lower than that of normal control group (P< 0 .05) .TSH had a negative correlated with the severity of depression , block and despair factor (r = -0 .320 ,-0 .345 ,-0 .290 ,respectively ;P < 0 .05) ,had a positive corre‐lated with the total number of correct and complete classification number in cognitive function ,and neg‐atively correlated with the total number of errors (r =0 .396 ,0 .476 ,-0 .325 ,respectively ;P < 0 .05);FT4 and anxiety somatization ,mental anxiety were positively correlated (r =0 .381 ,0 .320 ,respectively ;P< 0 .05);FT3 ,Anti-TPO were negatively correlated with diurnal variation (r = -0 .302 ,-0 .385 , respectively ;P< 0 .05) .Conclusions Depression patients exists the disturbance of thyroid ,disorders of thyroid function are connected with the severity of depression ,anxiety somatization factor ,block factor , despair factor and diurnal variation factor .Thyroid dysfunction can lead to abnormal cognitive function .
