CAJ | 학술논문

目的：研究首发精神分裂症患者血清中抗N －甲基－D －天冬氨酸受体（NMDAR）抗体浓度水平变化。方法用酶联免疫吸附技术（ELISA）测定80名健康对照和82例首发精神分裂症患者血清抗NMDAR抗体浓度水平。结果首发精神分裂症患者组血清抗NMDAR抗体浓度显著高于对照组[（208．84±113．60）pg／ml比（107．29±40．57）pg／ml ]，差异有统计学意义（t ＝－7．162，P ＜0.01）。患者组男、女血清抗NMDAR抗体浓度水平[（215．75±133．20）pg／ml比（200．00±83．14）pg／ml]差异无统计学意义（t＝0．621，P＞0．05）。精神分裂症患者血清抗NMDAR抗体浓度与PANSS总分、阳性症状分及阴性症状分均呈正相关（ r值分别为0．364，0．276，0．260；P＜0．05）。结论首发精神分裂症患者血清抗NMDAR抗体水平升高，与精神分裂症临床症状呈正相关。
목적：연구수발정신분렬증환자혈청중항N －갑기－D －천동안산수체（NMDAR）항체농도수평변화。방법용매련면역흡부기술（ELISA）측정80명건강대조화82례수발정신분렬증환자혈청항NMDAR항체농도수평。결과수발정신분렬증환자조혈청항NMDAR항체농도현저고우대조조[（208．84±113．60）pg／ml비（107．29±40．57）pg／ml ]，차이유통계학의의（t ＝－7．162，P ＜0.01）。환자조남、녀혈청항NMDAR항체농도수평[（215．75±133．20）pg／ml비（200．00±83．14）pg／ml]차이무통계학의의（t＝0．621，P＞0．05）。정신분렬증환자혈청항NMDAR항체농도여PANSS총분、양성증상분급음성증상분균정정상관（ r치분별위0．364，0．276，0．260；P＜0．05）。결론수발정신분렬증환자혈청항NMDAR항체수평승고，여정신분렬증림상증상정정상관。
Objective To explore serum level of anti-NMDAR antibodies in patients with first-episode schizophrenia .Methods The serum concentrations of anti -NMDAR antibodies in 80 healthy controls and 82 patients with first -episode schizophrenia were assessed by enzyme linked immunosor‐bent assay (ELISA) .Results The level of serum anti-NMDAR antibody in first-episode schizophreni‐a was observably higher than healthy controls[(208 .84 ± 113 .60)pg/ml vs(107 .29 ± 40 .57) pg/ml] , and the difference was statistically significant (t = - 7 .162 ,P < 0 .01) .The difference of serum anti-NMDAR antibody concentrations between men(215 .75 ± 133 .20)pg/ml and women(200 .00 ± 83 .14)pg/ml in patients with schizophrenia was no statistically significant (t= 0 .621 ,P> 0 .05) .The serum concentra‐tion of anti -NMDAR antibodies was positively correlated with PANSS total score ,the positive syn‐drome scores and the negative syndrome scores (r= 0 .364 ,0 .276 ,0 .260 ,respectively ;P< 0 .05) .Con‐clusions The level of serum antibody anti -NMDAR in first -episode schizophrenia is increased ,and there is a positive correlation with the clinical symptoms of schizophrenia .