CAJ | 학술논문

目的：通过横断面调查新诊断的2型糖尿病患者,寻找并发糖尿病肾病的危险因素,为临床早期干预糖尿病肾病提供科学依据。方法选取初发2型糖尿病患者120例,分为正常白蛋白尿组( NUA1b)和糖尿病肾病组( DN )。测定身高、体重、血压、肝肾功能、血糖、血脂、尿酸、糖化血红蛋白和胰岛素浓度。结果 DN组HbA1C、TG、Cr、UA、FBG、PBG、LnHOMA-IR均高于 NUA1b组；LnUACR与 LnHOMA-IR、PBG、FBG、Cr、TG呈正相关；多元逐步回归分析显示,FBG、Cr、TG和LnHOMA-IR是独立的影响因子。结论早期发现高血糖、血脂异常和胰岛素抵抗,对糖尿病肾病的发生具有预警作用。
목적：통과횡단면조사신진단적2형당뇨병환자,심조병발당뇨병신병적위험인소,위림상조기간예당뇨병신병제공과학의거。방법선취초발2형당뇨병환자120례,분위정상백단백뇨조( NUA1b)화당뇨병신병조( DN )。측정신고、체중、혈압、간신공능、혈당、혈지、뇨산、당화혈홍단백화이도소농도。결과 DN조HbA1C、TG、Cr、UA、FBG、PBG、LnHOMA-IR균고우 NUA1b조；LnUACR여 LnHOMA-IR、PBG、FBG、Cr、TG정정상관；다원축보회귀분석현시,FBG、Cr、TG화LnHOMA-IR시독립적영향인자。결론조기발현고혈당、혈지이상화이도소저항,대당뇨병신병적발생구유예경작용。
Objective Cross-sectional survey to analyze the incidence and risk factors of microalbuminuria in newly diagnosed type 2 diabetes patients, and to provide the theoretical basis for therapy of diabetes nephropathy. Method One hundred and twenty patients with newly diagnosed type 2 diabetes mellitus were enrolled. Subjects were divided into two groups according urine albumin-to-creatinine ratio (UACR):normoalbuminuria (NUA1b) group and dia-betic nephropathy ( DN) group. All subjects were measured height, weight, blood pressure, hepatic and renal func-tion, uric acid(UA), lipid profile, insulin and HbA1c. Result HbA1c、triglyceride(TG)、creatinine(Cr)、UA、fast-ing blood gluose( FBG)、postprandial blood glucose( PBG)、HOMA-IR were significantly higher in DN group than in NUA1b group(HbA1c:[8. 2±2. 9]% vs [7. 8±2. 1]%, P<0. 05;TG:[5. 36±3. 62]mmol/L vs [1. 57±0. 86] mmol/L, P<0. 05;Cr [86±39] μmol/L vs [71±16]μmol/L, P<0. 05; UA [332±77] μmol/L vs [295±82]μmol/L, P<0. 05;FBG [10. 4±4. 7]mmol/L vs [8. 3±2. 9]mmol/L,P<0. 05;PBG [15. 4±7. 6]mmol/L vs [11. 9±4. 7]mmol/L, P<0. 05;HOMA-IR [1. 41±0. 60] vs [1. 01±0. 73], P<0. 05). There existed positive correla-tion between UACR and HOMA-IR(r=0. 247, P<0. 05)、PBG(r=0. 231, P<0. 05)、FBG(r=0. 249, P<0. 01)、Cr(r=0. 387, P<0. 01)、TG(r=0. 396, P<0. 01). Stepwise multiple regression analysis revealed that FBG、Cr、TG and HOMA-IR were independently risk factors of microalbuminuia. Conclusion Hyperglycemia, insulin resistance and abnormal lipid profile, maybe the risk factors of diabetic nephropathy.