CAJ | 학술논문

目的：探讨坦度螺酮辅助治疗精神分裂症患者的临床疗效及认知功能改善效果。方法64例精神分裂症患者随机分为对照组32例和研究组32例，治疗12周。治疗前及治疗后第12周末分别进行阳性和阴性症状量表（PANSS）、韦氏成人智力量表（WAIS‐RC）、韦氏记忆量表（WMS）、威斯康星卡片分类测验（WCST）及不良反应症状量表（TESS）测定以评定疗效及不良反应。结果治疗第12周末研究组WCST 的总测验数、持续错误数、随机错误数评分显著低于对照组（ P＜0.05），临床有效率、WAIS‐RC的语言量表、操作量表、总智商量表、WMS总分评分显著高于对照组（P＜0.05）。2组TESS评分差异无统计学意义（P＞0.05）。结论坦度螺酮可明显改善精神分裂患者的精神症状及认知功能，且安全性较高。
목적：탐토탄도라동보조치료정신분렬증환자적림상료효급인지공능개선효과。방법64례정신분렬증환자수궤분위대조조32례화연구조32례，치료12주。치료전급치료후제12주말분별진행양성화음성증상량표（PANSS）、위씨성인지역량표（WAIS‐RC）、위씨기억량표（WMS）、위사강성잡편분류측험（WCST）급불량반응증상량표（TESS）측정이평정료효급불량반응。결과치료제12주말연구조WCST 적총측험수、지속착오수、수궤착오수평분현저저우대조조（ P＜0.05），림상유효솔、WAIS‐RC적어언량표、조작량표、총지상량표、WMS총분평분현저고우대조조（P＜0.05）。2조TESS평분차이무통계학의의（P＞0.05）。결론탄도라동가명현개선정신분렬환자적정신증상급인지공능，차안전성교고。
Objective To discussion clinical efficacy of tandospirone in the adjuvant treatment of schizophrenia and its effects on cognitive function.Methods 64 patients with schizophrenia were randomly divided into control group (n=32) and the study group (n=32) for 12 weeks observation. Before treatment and after 12‐week treatment ,positive and negative syn‐drome scale (PANSS) ,the Wechsler Adult Intelligence Scale (WAIS‐RC) ,Wechsler Memory Scale (WMS) ,Wisconsin Card Sorting Test (WCST) and adverse reactions symptom Scale (TESS) were performed in order to assess the efficacy and adverse reactions.Results After 12‐week treatment ,the total number of WCST test ,continuous errors scores ,random errors scores in study group were significantly lower than that in the control group (P<0.05);Meanwhile ,the total clinical efficacy ,WAIS‐RC Language Scale scores ,Performance Scale scores ,the total IQ scale scores ,WMS Scale scores of study group were signifi‐cantly higher than that of control group(P<0.05). TESS scores between the two groups showed no statistically significant difference(P> 0.05). Conclusion Tandospirone can significantly improve psychiatric symptoms and cognitive function in schizophrenia patients with higher security.