中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
25期
63-65,66
,共4页
重症%并发感染%IL-6
重癥%併髮感染%IL-6
중증%병발감염%IL-6
Severe%Concurrent infections%IL-6
目的：研究IL-6水平检测与重症并发感染者的相关性。方法：选择2013年1月-2014年12月本院接诊的73例重症患者（APACHEⅡ评分>12），按照是否并发感染分为重症并发感染组（41例）和重症非并发感染组（32例），并随机从本院健康体检的人群中选择30例正常者作为对照组，使用放射免疫分析法测定三组血清IL-6水平，比较并分析IL-6水平与APACHEⅡ评分的相关性。结果：重症非并发感染组患者的血清IL-6水平（131.25±51.82）pg/mL明显高于对照组（83.98±31.15）pg/mL，重症并发感染组的血清IL-6水平（154.08±53.06）pg/mL亦明显高于对照组，比较差异均有统计学意义（P<0.05）；但重症非并发感染组的血清IL-6水平与重症并发感染组比较，差异无统计学意义（P>0.05）。重症非并发感染组患者的血清IL-6水平与其APACHEⅡ评分呈正相关关系（r=0.793，P=0.0004）；重症并发感染组患者的血清IL-6水平与其APACHEⅡ评分亦呈正相关关系（r=0.864，P=0.0001）。重症非并发感染组和并发感染组血清IL-6阳性率均明显高于对照组，比较差异均有统计学意义（P<0.05）。结论：重症患者无论是否并发感染，其血清IL-6水平均显著升高，且IL-6水平升高程度与患者损伤的严重程度呈正相关。
目的：研究IL-6水平檢測與重癥併髮感染者的相關性。方法：選擇2013年1月-2014年12月本院接診的73例重癥患者（APACHEⅡ評分>12），按照是否併髮感染分為重癥併髮感染組（41例）和重癥非併髮感染組（32例），併隨機從本院健康體檢的人群中選擇30例正常者作為對照組，使用放射免疫分析法測定三組血清IL-6水平，比較併分析IL-6水平與APACHEⅡ評分的相關性。結果：重癥非併髮感染組患者的血清IL-6水平（131.25±51.82）pg/mL明顯高于對照組（83.98±31.15）pg/mL，重癥併髮感染組的血清IL-6水平（154.08±53.06）pg/mL亦明顯高于對照組，比較差異均有統計學意義（P<0.05）；但重癥非併髮感染組的血清IL-6水平與重癥併髮感染組比較，差異無統計學意義（P>0.05）。重癥非併髮感染組患者的血清IL-6水平與其APACHEⅡ評分呈正相關關繫（r=0.793，P=0.0004）；重癥併髮感染組患者的血清IL-6水平與其APACHEⅡ評分亦呈正相關關繫（r=0.864，P=0.0001）。重癥非併髮感染組和併髮感染組血清IL-6暘性率均明顯高于對照組，比較差異均有統計學意義（P<0.05）。結論：重癥患者無論是否併髮感染，其血清IL-6水平均顯著升高，且IL-6水平升高程度與患者損傷的嚴重程度呈正相關。
목적：연구IL-6수평검측여중증병발감염자적상관성。방법：선택2013년1월-2014년12월본원접진적73례중증환자（APACHEⅡ평분>12），안조시부병발감염분위중증병발감염조（41례）화중증비병발감염조（32례），병수궤종본원건강체검적인군중선택30례정상자작위대조조，사용방사면역분석법측정삼조혈청IL-6수평，비교병분석IL-6수평여APACHEⅡ평분적상관성。결과：중증비병발감염조환자적혈청IL-6수평（131.25±51.82）pg/mL명현고우대조조（83.98±31.15）pg/mL，중증병발감염조적혈청IL-6수평（154.08±53.06）pg/mL역명현고우대조조，비교차이균유통계학의의（P<0.05）；단중증비병발감염조적혈청IL-6수평여중증병발감염조비교，차이무통계학의의（P>0.05）。중증비병발감염조환자적혈청IL-6수평여기APACHEⅡ평분정정상관관계（r=0.793，P=0.0004）；중증병발감염조환자적혈청IL-6수평여기APACHEⅡ평분역정정상관관계（r=0.864，P=0.0001）。중증비병발감염조화병발감염조혈청IL-6양성솔균명현고우대조조，비교차이균유통계학의의（P<0.05）。결론：중증환자무론시부병발감염，기혈청IL-6수평균현저승고，차IL-6수평승고정도여환자손상적엄중정도정정상관。
Objective: To research the relevance of IL-6 levels and severely infected person with infection. Method: 73 severe illness patients (APACHEⅡ score>12) from January 2013 to December 2014 in our hospital were selected and divided, according to whether concurrent infection complicated, into severe infection group (41 cases) and non-concurrent infection group (32 cases), and 30 normal healthy cases were randomly selected from our hospital as control group. The serum IL-6 level was detected by using radioimmunoassay. To compare three groups IL-6 levels and a correlation of IL-6 levels and APACHEⅡscores.Result: The serum IL-6 level of the severe non-concurrent infection group (131.25±51.82)pg/mL was significantly higher than that of the control group (83.98±31.15)pg/mL, and the difference was statistically significant (P<0.05). And that of the severe concurrent infection group was (154.08±53.06) pg/mL, which was significantly higher than that of the control group, the difference was statistically significant (P<0.05), too. The difference of serum IL-6 level between the severe non-concurrent infection group and severe concurrent infection group was not significant (P>0.05). Serum IL-6 level of the severe non-concurrent infection group and its APACHEⅡscore showed a positive correlation (r=0.793,P=0.0004). Serum IL-6 level of infected patients with severe concurrent and its APACHEⅡ scores were positively correlated (r=0.864,P=0.0001). Serum IL-6 positive rate of the severe non-concurrent infection group was significantly higher than that of the control group, severe concurrent infection serum IL-6 positive rate was significantly higher that of the control group, the difference was statistically significant (P<0.05).Conclusion: Whether concurrent infection in critically ill patients, serum IL-6 levels are significantly elevated, and increasing degree of IL 6-levels is positively correlated with severity of patient injury.
