肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2015年
4期
342-343,344
,共3页
羟考酮%尼松%术后镇痛%肝癌
羥攷酮%尼鬆%術後鎮痛%肝癌
간고동%니송%술후진통%간암
ketorolac tromethamine injeton%oxycodone%postoperative analgesia%liver cancer
目的：观察羟考酮联合尼松对肝癌切除术后镇痛的效果。方法选择行择期肝癌切除术患者60例，随机均分为2组：尼松+羟考酮组（KO 组）和尼松+芬太尼组（KF 组）。2组手术结束前30 min 均给予尼松30 mg 预先镇痛，手术结束时2组患者分别静脉注射羟考酮10 mg、芬太尼0.1 mg，术后均用舒芬太尼2μg·kg -1和托烷司琼10 mg，生理盐水稀释至200 mL 入镇痛泵。评估2组患者在入麻醉复苏室（PACU）醒后30 min、60 min 和离开 PACU 时的深腹部疼痛强度 NRS 评分，追加镇痛药物和上腹部不适等的发生情况。结果与 KF 组比较，KO 组术后不同时点 NRS 评分均明显降低（P <0.05）；镇痛药物追加例数明显减少（P <0.05）；上腹部不适感发生率明显降低（P <0.05）。结论羟考酮联合尼松的术后镇痛方案安全可行，可为肝癌切除术患者提供有效的术后镇痛，且不良事件少，更有利于患者术后康复。
目的：觀察羥攷酮聯閤尼鬆對肝癌切除術後鎮痛的效果。方法選擇行擇期肝癌切除術患者60例，隨機均分為2組：尼鬆+羥攷酮組（KO 組）和尼鬆+芬太尼組（KF 組）。2組手術結束前30 min 均給予尼鬆30 mg 預先鎮痛，手術結束時2組患者分彆靜脈註射羥攷酮10 mg、芬太尼0.1 mg，術後均用舒芬太尼2μg·kg -1和託烷司瓊10 mg，生理鹽水稀釋至200 mL 入鎮痛泵。評估2組患者在入痳醉複囌室（PACU）醒後30 min、60 min 和離開 PACU 時的深腹部疼痛彊度 NRS 評分，追加鎮痛藥物和上腹部不適等的髮生情況。結果與 KF 組比較，KO 組術後不同時點 NRS 評分均明顯降低（P <0.05）；鎮痛藥物追加例數明顯減少（P <0.05）；上腹部不適感髮生率明顯降低（P <0.05）。結論羥攷酮聯閤尼鬆的術後鎮痛方案安全可行，可為肝癌切除術患者提供有效的術後鎮痛，且不良事件少，更有利于患者術後康複。
목적：관찰간고동연합니송대간암절제술후진통적효과。방법선택행택기간암절제술환자60례，수궤균분위2조：니송+간고동조（KO 조）화니송+분태니조（KF 조）。2조수술결속전30 min 균급여니송30 mg 예선진통，수술결속시2조환자분별정맥주사간고동10 mg、분태니0.1 mg，술후균용서분태니2μg·kg -1화탁완사경10 mg，생리염수희석지200 mL 입진통빙。평고2조환자재입마취복소실（PACU）성후30 min、60 min 화리개 PACU 시적심복부동통강도 NRS 평분，추가진통약물화상복부불괄등적발생정황。결과여 KF 조비교，KO 조술후불동시점 NRS 평분균명현강저（P <0.05）；진통약물추가례수명현감소（P <0.05）；상복부불괄감발생솔명현강저（P <0.05）。결론간고동연합니송적술후진통방안안전가행，가위간암절제술환자제공유효적술후진통，차불량사건소，경유리우환자술후강복。
Objective To observe the efficacy of ketorolac tromethamine injeton combined with oxycodone for postoperative analgesia in the resection of liver cancer. Methods Sixty patients received resection of liver cancer were randomly divided into two groups:the ketorolac tromethamine injeton plus oxycodone group( the KO group) and the ketorolac tromethamine injeton plus fentanil group(the KF group). Patients in the KO group received 10 mg oxycodone,and patients in the KF group received 0. 1 mg fentanil before skin closure. In the 30 minutes before the end of surgery,all the patients received 30 mg ketorolac tromethamine injeton and controlled intravenous analgesia with sufentanil 2 μg·kg - 1 plus 10 mg tropisetron diluted to 200 mL with normal saline. The NRS scores(30 min, 60 min postoperatively and after PACU),additional analgesic drugs and complications were compared. Results Compared with the KF group,the NRS scores,additional analgesic drugs and complications were significantly decreasd in the KO group(P <0. 05). Conclusion The combination of ketorolac tromethamine injeton and oxycodone can pro-vide more effective postoperative analgesia to patients,as well as less complications in the resection of liver cancer.
