中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
16期
3087-3090
,共4页
s100蛋白质类%自身免疫性疾病
s100蛋白質類%自身免疫性疾病
s100단백질류%자신면역성질병
s100 proteins%Autoimmune disease
s100a8/a9为钙结合蛋白s100蛋白家族两个重要成员。二者通常以钙离子依赖性方式形成异源二聚体（s100a8/a9）蛋白复合物在炎症及免疫中发挥作用。近年来研究发现，s100a8/a9在多种疾病中高表达，特别是自身免疫性疾病（如系统性红斑狼疮、类风湿关节炎、炎性肠病等），推测s100a8/a9对自身免疫性疾病发生发展具有重要作用，可为自身免疫性疾病的治疗提供新依据。
s100a8/a9為鈣結閤蛋白s100蛋白傢族兩箇重要成員。二者通常以鈣離子依賴性方式形成異源二聚體（s100a8/a9）蛋白複閤物在炎癥及免疫中髮揮作用。近年來研究髮現，s100a8/a9在多種疾病中高錶達，特彆是自身免疫性疾病（如繫統性紅斑狼瘡、類風濕關節炎、炎性腸病等），推測s100a8/a9對自身免疫性疾病髮生髮展具有重要作用，可為自身免疫性疾病的治療提供新依據。
s100a8/a9위개결합단백s100단백가족량개중요성원。이자통상이개리자의뢰성방식형성이원이취체（s100a8/a9）단백복합물재염증급면역중발휘작용。근년래연구발현，s100a8/a9재다충질병중고표체，특별시자신면역성질병（여계통성홍반랑창、류풍습관절염、염성장병등），추측s100a8/a9대자신면역성질병발생발전구유중요작용，가위자신면역성질병적치료제공신의거。
s100a8 and s100a9 are two important members of the calcium-binding protein from s100 protein family. S100a8 and S100a9 which usually form a heterodimers in a calcium-dependent way play a role in inflammation and immunity. Recent studies have found that s100a8/a9 highly expressed in different diseases, especially autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, etc). It speculates that s100a8/a9 has an important role in initiation and progress of autoimmune disease, which can provide a new basis for the treatment of autoimmune diseases.
