CAJ | 학술논문

系统性红斑狼疮是一种异质性自身免疫性疾病，其发病机制尚未明确，但常涉及免疫系统的紊乱。正常免疫应答的发生、调节和保持，需要所有T细胞亚群的功能处于一种平衡状态。因此，T细胞亚群分布紊乱及其不同亚群的活化和功能异常在SLE发生发展中有重要作用。而其中，其分泌的细胞因子网络的紊乱处于中心位置。本文就Th细胞相关因子在SLE中的产生及功能异常，分析它们可能的致病机制以及作为治疗靶点的可能性。
계통성홍반랑창시일충이질성자신면역성질병，기발병궤제상미명학，단상섭급면역계통적문란。정상면역응답적발생、조절화보지，수요소유T세포아군적공능처우일충평형상태。인차，T세포아군분포문란급기불동아군적활화화공능이상재SLE발생발전중유중요작용。이기중，기분비적세포인자망락적문란처우중심위치。본문취Th세포상관인자재SLE중적산생급공능이상，분석타문가능적치병궤제이급작위치료파점적가능성。
Systemic lupus erythematosus (SLE) is a heterogenic autoimmune inflammatory disease. Though the pathogenesis of SLE is still incompletely deciphered, the disorder of immune is involved. The functional homeostasis of T cell subsets is required for the occurrence, regulation and maintenance of normal immune response. Thus, the abnormal distribution, activation or function of T cell subsets play a crucial role in the development of SLE. Among them, the dysregulation of cytokines networks in the center position. In this paper, we elaborated on the abnormal secretion and functions of T helper (Th) cell associated cytokines in SLE, analyzed their potential pathogenic roles, and probed into the possibility of them being utilized as targets for therapy.