CAJ | 학술논문

目的：探讨氨氯地平瑞舒伐他汀钙片治疗高血压合并冠心病的临床效果以及炎症反应。方法：研究对象选取本院2013年1月-2014年1月高血压合并冠心病患者100例，按照随机抽签法分为对照组与观察组，每组50例。对照组患者采用硝苯地平治疗，观察组患者采用氨氯地平瑞舒伐他汀钙片治疗。对比两组患者治疗前后血压水平、心电图改善情况以及不良反应出现率。结果：治疗后，观察组总有效率为98.00%。优于对照组32.00%。治疗后观察组患者血管收缩压、舒张压平均值明显优于对照组且治疗总有效率明显高于对照组，比较差异具有统计学意义（P<0.05）。治疗后，两组患者hs-CRP、IL-18、C-myc、Bcl-2水平比较，差异无统计学意义（P>0.05）。结论：氨氯地平瑞舒伐他汀钙片在治疗高血压合并冠心病方面疗效确切，在有效降压、降血脂作用外，其还有抗炎、抗凋亡临床效果，值得进行临床推广应用。
목적：탐토안록지평서서벌타정개편치료고혈압합병관심병적림상효과이급염증반응。방법：연구대상선취본원2013년1월-2014년1월고혈압합병관심병환자100례，안조수궤추첨법분위대조조여관찰조，매조50례。대조조환자채용초분지평치료，관찰조환자채용안록지평서서벌타정개편치료。대비량조환자치료전후혈압수평、심전도개선정황이급불량반응출현솔。결과：치료후，관찰조총유효솔위98.00%。우우대조조32.00%。치료후관찰조환자혈관수축압、서장압평균치명현우우대조조차치료총유효솔명현고우대조조，비교차이구유통계학의의（P<0.05）。치료후，량조환자hs-CRP、IL-18、C-myc、Bcl-2수평비교，차이무통계학의의（P>0.05）。결론：안록지평서서벌타정개편재치료고혈압합병관심병방면료효학절，재유효강압、강혈지작용외，기환유항염、항조망림상효과，치득진행림상추엄응용。
Objective: To investigate the amlodipine rosuvastatin calcium tablets in treatment of hypertension and coronary heart disease clinical effect and inflammatory reaction.Method: The study objects were 100 patients with hypertension and coronary heart disease in our hospital from January 2013 to January 2014, and were randomly divided into control group and observation group, 50 cases in each group. The control group was treated with nifedipine, the observation group was treated with amlodipine rosuvastatin calcium. To compare level of blood pressure, ECG improvement and adverse reaction rate between the two groups.Result: After treatment, the total effective rate of the observation group was 98.00%, which was higher than 32.00% of the control group. After treatment, coronary artery disease average systolicand diastolic blood pressure values of the observation group was better than that of the control group, the difference was statistically significant (P<0.05). After treatment, hs-CRP, IL-18, C-myc, and Bcl-2 level between the two groups had no significant difference (P>0.05).Conclusion: Amlodipine rosuvastatin calcium tablet in the treatment of hypertension and coronary heart disease curative effect, in the effective antihypertensive and hypolipidemic effect, its anti-inflammatory and anti apoptosis and clinical efficacy, is worthy of clinical application.