CAJ | 학술논문

目的：观察重组人白介素-11衍生物（百杰依）对恶性肿瘤患者化疗后血小板减少的疗效与不良反应。方法采用自身对照的方法，对化疗后血小板减少至50×109/L以下的肿瘤患者16例给予百杰依25μg/kg·d，皮下注射，连用3～10天，连用百杰依10天或血小板计数升高5个绝对值时停药。观察血小板计数变化情况及不良反应。结果经百杰依治疗后16例肿瘤患者的血小板计数均显著高于治疗前，差异有统计学意义（P＜0.05）。治疗后血小板持续在≥100×109/L以上的时间也显著长于治疗前，差异有统计学意义（P＜0.05）。不良反应以Ⅰ～Ⅱ级乏力、水肿为主。结论百杰依对化疗药物引起的血小板减少具有确切的疗效，不良反应轻微，耐受性较好，对提高化疗效果有帮助，可广泛应用于临床。
목적：관찰중조인백개소-11연생물（백걸의）대악성종류환자화료후혈소판감소적료효여불량반응。방법채용자신대조적방법，대화료후혈소판감소지50×109/L이하적종류환자16례급여백걸의25μg/kg·d，피하주사，련용3～10천，련용백걸의10천혹혈소판계수승고5개절대치시정약。관찰혈소판계수변화정황급불량반응。결과경백걸의치료후16례종류환자적혈소판계수균현저고우치료전，차이유통계학의의（P＜0.05）。치료후혈소판지속재≥100×109/L이상적시간야현저장우치료전，차이유통계학의의（P＜0.05）。불량반응이Ⅰ～Ⅱ급핍력、수종위주。결론백걸의대화료약물인기적혈소판감소구유학절적료효，불량반응경미，내수성교호，대제고화료효과유방조，가엄범응용우림상。
Objective To observe the efficacy and the side effects of rhIL-11 derivatives on malignant tumor patients suffering from thrombocytopenia after chemotherapy.Methods The test adopted own control , thrombolytic count of 16 patients with malignant tumor after chemotherapy was less than 50×109/L ,then they received hypodermic injection baijieyi 25μg/ kg·d which lasts 3~10 days.Stop using when they have received hypodermic injection baijieyi 10 days continuously or the thrombolytic count came to 100×109/L.The change of thrombolytic count and side effects of baijieyi (rhIL-11derivatives) was observed.Results Thrombolytic count of 16 patients with malignant tumor after injecting baijieyi was obviously higher than before (P<0.05).And the duration of thrombolytic count which is over 100×109/L, was also obviously longer than before (P<0.05).Major side effect included fatigue and edema.Conclusions The baijieyi could elevate thrombocytopenia induced by chemotherapy in malignant tumor patients with slight side-effects and good tolerace, could help improve the efficacy of chemotherapy and adopt to clinic on a large scale.