CAJ | 학술논문

目的：探讨口腔颌面部良性肿瘤发病的影响因素。方法病例组来源于2010年9月至2015年1月于福建某医院确诊的口腔颌面部良性肿瘤新发病例113例。同期选取符合标准的社区人群作为对照组，共584名。通过问卷调查收集研究对象的人口学特征、吸烟史、饮酒史、饮食习惯、口腔卫生情况、肿瘤家族史等，应用非条件logistic回归模型分析探讨相关因素与口腔颌面部良性肿瘤的关系。结果多因素分析结果显示，口腔颌面部良性肿瘤的危险因素有：吸烟指数>1000、18岁前被动吸烟、开始戴假牙年龄（35~55岁）及高血压，其OR(95%CI)值分别为14.63(3.88~55.13)、2.34(1.19~4.62)、2.35(1.17~4.73)、3.46(1.71~7.00)；保护因素有：进食肉类≥1次/d、进食水果、服用保健品、补充维生素片，刷牙频率>1次/d及进行口腔检查≥5年/次，其OR（95%CI）值分别为0.22(0.07~0.70)、0.18(0.08~0.41)、0.32(0.11~0.88)、0.22(0.07~0.73)、0.28(0.16~0.48)、0.28(0.13~0.60)。结论禁止吸烟、减少18岁前被动吸烟、规律的食用肉类、水果、保健品、维生素片以及定期检查口腔卫生有助于减少口腔颌面部良性肿瘤的发生。
목적：탐토구강합면부량성종류발병적영향인소。방법병례조래원우2010년9월지2015년1월우복건모의원학진적구강합면부량성종류신발병례113례。동기선취부합표준적사구인군작위대조조，공584명。통과문권조사수집연구대상적인구학특정、흡연사、음주사、음식습관、구강위생정황、종류가족사등，응용비조건logistic회귀모형분석탐토상관인소여구강합면부량성종류적관계。결과다인소분석결과현시，구강합면부량성종류적위험인소유：흡연지수>1000、18세전피동흡연、개시대가아년령（35~55세）급고혈압，기OR(95%CI)치분별위14.63(3.88~55.13)、2.34(1.19~4.62)、2.35(1.17~4.73)、3.46(1.71~7.00)；보호인소유：진식육류≥1차/d、진식수과、복용보건품、보충유생소편，쇄아빈솔>1차/d급진행구강검사≥5년/차，기OR（95%CI）치분별위0.22(0.07~0.70)、0.18(0.08~0.41)、0.32(0.11~0.88)、0.22(0.07~0.73)、0.28(0.16~0.48)、0.28(0.13~0.60)。결론금지흡연、감소18세전피동흡연、규률적식용육류、수과、보건품、유생소편이급정기검사구강위생유조우감소구강합면부량성종류적발생。
Objective To investigate the clinical influence factors of oral-maxillofacial benign tumors. Methods We conducted a case-control study with 113 cases newly diagnosed primary oral-maxillofacial benign tumors and 584 cases controls from a hospital in Fujian from September 2010 to January 2015. Epidemiological data were collected by in-person interviews using a standard questionnaire. The contents of the questionnaire included demography character, history of tobacco smoking and alcohol drinking, dietary habits, oral hygiene status, family history of cancer, etc. Unconditional logistic regression was used to research the relationship between the factors and oral-maxillofacial benign tumors. Results Multivariable analysis showed that risk factors of oral-maxillofacial benign tumors included: cigarette smoking index above 1 000, passive smoking before the age of 18, age of wearing bad prosthesis between 33 to 55 years old and high blood pressure; the corresponding OR(95%CI) values were 14.63 (3.88-55.13), 2.34 (1.19-4.62), 2.35 (1.17-4.73), 3.46(1.71-7.00), respectively; Protective factors included: regularly intake of meat above 1 time/day, fruits, health care products and vitamin tablets, brushing teeth above 1 time per day and oral examination above 5 years/time, the corresponding OR(95%CI) values were 0.22 (0.07-0.70), 0.18 (0.08- 0.41), 0.32 (0.11- 0.88), 0.22 (0.07- 0.73), 0.28 (0.16-0.48), 0.28 (0.13-0.60), respectively. Conclusion Abstinence from tobacco smoking, reduce passive smoking before the age of 18, regularly intake of meat, fruits, health care products and vitamin tablets, and oral examination at regular time might have impact on the incidence of oral-maxillofacial benign tumors to a certain extent.