CAJ | 학술논문

目的：探讨对抑郁症患者使用度洛西汀联合艾司西酞普兰治疗的临床效果。方法：选取本院精神科和中山市人民医院心理科收治的抑郁症患者128例作为研究对象，对照组1（40例）使用度洛西汀治疗，对照组2（40例）使用艾司西酞普兰治疗，观察组48例联合使用上述药物，对比三组临床效果。结果：观察组治疗总有效率为83.3%，高于对照组1的72.5%与对照组2的75.0%，比较差异有统计学意义（P<0.05）；治疗后观察组HAMD评分显著低于对照组1、2，比较差异有统计学意义（P<0.05）；三组不良反应发生率比较差异无统计学意义（P>0.05）。结论：对抑郁症患者使用度洛西汀联合艾司西酞普兰治疗效果明显，有推广价值。
목적：탐토대억욱증환자사용도락서정연합애사서태보란치료적림상효과。방법：선취본원정신과화중산시인민의원심이과수치적억욱증환자128례작위연구대상，대조조1（40례）사용도락서정치료，대조조2（40례）사용애사서태보란치료，관찰조48례연합사용상술약물，대비삼조림상효과。결과：관찰조치료총유효솔위83.3%，고우대조조1적72.5%여대조조2적75.0%，비교차이유통계학의의（P<0.05）；치료후관찰조HAMD평분현저저우대조조1、2，비교차이유통계학의의（P<0.05）；삼조불량반응발생솔비교차이무통계학의의（P>0.05）。결론：대억욱증환자사용도락서정연합애사서태보란치료효과명현，유추엄개치。
Objective: To explore the clinical effect of duloxetine in combination of escitalopram for patients with depression.Method: 128 patients who were admitted in the psychiatry department of our hospital and psychological department of Zhongshan People’s Hospital were chosen as research objects. They were divided into control group 1 (40 patients), control group 2 (40 patients), and observation group (48 patients). Patients in the control group 1 were cured with the application of duloxetine, and the control group 2 with escitalopram while patients in the observation group were cured with combination of the two kinds of medicine. The clinical effect of the three groups was compared.Result: The total effective rate of the observation group was 83.3%, which was higher than 72.5% of the control group 1, and 75.0% of the control group 2. The difference was statistically significant (P<0.05). After treatment, HAMD grade of the observation groupwas remarkably lower than that of the two control groups, which had statistical significance (P<0.05). The contrast difference in incidence of adverse reactions of the three groups had no statistical significance (P>0.05).Conclusion: Duloxetine in combination of escitalopram for patients with depression has obvious clinical effect. It is worth of promotion.