中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
16期
3015-3018
,共4页
李晟%林振文%陈曦%陈亮%程珠琴%肖辉煌
李晟%林振文%陳晞%陳亮%程珠琴%肖輝煌
리성%림진문%진희%진량%정주금%초휘황
伊托必利%长期卧床%呼吸道感染%发病率%死亡率
伊託必利%長期臥床%呼吸道感染%髮病率%死亡率
이탁필리%장기와상%호흡도감염%발병솔%사망솔
Itopride%Long-term bed gerontal%Respiratory tract infections%Incidence%Mortality
目的：探讨伊托必利促胃肠动力干预措施对长期卧床老年患者肺部感染的防治价值。方法采用前瞻性、随机、对照设计，将年龄＞60岁、长期卧床、神志清楚、反流性疾病问卷阳性患者分为药物治疗组（伊托必利，A 组）和对照组（B 组），比较两组患者吸入性肺炎（AP）发病率、医院内获得性肺炎（HAP）发病率、相对危险度、肺部感染的粗死亡率、归因死亡率、临床肺部感染评分、急性生理与慢性健康评分系统Ⅱ评分、住院时间及肺部感染持续时间。结果 A组HAP发病率低于B组（P＜0.05）。两组患者肺部感染的粗死亡率、归因死亡率、CPIS与APACHEⅡ评分的差异无统计学意义（P＞0.05）。A组住院时间、感染持续时间均较B组短，差异有统计学意义（P＜0.05）。结论伊托必利可降低长期卧床胃食管反流高风险的老年患者HAP发病率，缩短患者住院时间及肺部感染持续时间，但不影响患者的死亡率。
目的：探討伊託必利促胃腸動力榦預措施對長期臥床老年患者肺部感染的防治價值。方法採用前瞻性、隨機、對照設計，將年齡＞60歲、長期臥床、神誌清楚、反流性疾病問捲暘性患者分為藥物治療組（伊託必利，A 組）和對照組（B 組），比較兩組患者吸入性肺炎（AP）髮病率、醫院內穫得性肺炎（HAP）髮病率、相對危險度、肺部感染的粗死亡率、歸因死亡率、臨床肺部感染評分、急性生理與慢性健康評分繫統Ⅱ評分、住院時間及肺部感染持續時間。結果 A組HAP髮病率低于B組（P＜0.05）。兩組患者肺部感染的粗死亡率、歸因死亡率、CPIS與APACHEⅡ評分的差異無統計學意義（P＞0.05）。A組住院時間、感染持續時間均較B組短，差異有統計學意義（P＜0.05）。結論伊託必利可降低長期臥床胃食管反流高風險的老年患者HAP髮病率，縮短患者住院時間及肺部感染持續時間，但不影響患者的死亡率。
목적：탐토이탁필리촉위장동력간예조시대장기와상노년환자폐부감염적방치개치。방법채용전첨성、수궤、대조설계，장년령＞60세、장기와상、신지청초、반류성질병문권양성환자분위약물치료조（이탁필리，A 조）화대조조（B 조），비교량조환자흡입성폐염（AP）발병솔、의원내획득성폐염（HAP）발병솔、상대위험도、폐부감염적조사망솔、귀인사망솔、림상폐부감염평분、급성생리여만성건강평분계통Ⅱ평분、주원시간급폐부감염지속시간。결과 A조HAP발병솔저우B조（P＜0.05）。량조환자폐부감염적조사망솔、귀인사망솔、CPIS여APACHEⅡ평분적차이무통계학의의（P＞0.05）。A조주원시간、감염지속시간균교B조단，차이유통계학의의（P＜0.05）。결론이탁필리가강저장기와상위식관반류고풍험적노년환자HAP발병솔，축단환자주원시간급폐부감염지속시간，단불영향환자적사망솔。
Objective To explore the value of Itopride prokinetic intervention measures to control long-term pulmonary infection in elderly patients in long-term bed. Methods The age>60 years old, long-term bedridden, sane, reflux disease questionnaire positive patients were divided into drug group (Itopride treated, A group) and control group (B group) in a prospective, randomized, controlled design. Compared the 2 groups of patients with the incidence of aspiration pneumonia (AP), acquired nosocomial pneumonia (HAP), relative risk, crude mortality, pulmonary infection attributable mortality, clinical pulmonary infection score, acute physiology and chronic health score system Ⅱ score, duration of hospitalization time and pulmonary infection. Results In A group, the incidence rate of HAP, the duration of hospitalization time and pulmonary infection was less than in B group (P<0.05). The 2 groups were no statistical significance in the the incidence rate of HAP crude mortality, pulmonary infection attributable mortality, clinical pulmonary infection score, acute physiology and chronic health score system Ⅱ score (P>0.05). Conclusion Itopride may reduce the incidence of HAP in elderly bed ridden patients with gastroesophageal reflux of high risk rate, shorten the time and duration of hospitalization in patients with pulmonary infection, but did not affect the mortality of patients.
