中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
16期
3006-3009
,共4页
汤永峰%蔡超%陈果%蔡志锻%李博伟%叶剑恒%吴永定%钟惟德%韩兆冬
湯永峰%蔡超%陳果%蔡誌鍛%李博偉%葉劍恆%吳永定%鐘惟德%韓兆鼕
탕영봉%채초%진과%채지단%리박위%협검항%오영정%종유덕%한조동
双特异性磷酸酶 5%前列腺增生%前列腺癌%Gleason评分%实时荧光定量聚合酶链反应%组织芯片
雙特異性燐痠酶 5%前列腺增生%前列腺癌%Gleason評分%實時熒光定量聚閤酶鏈反應%組織芯片
쌍특이성린산매 5%전렬선증생%전렬선암%Gleason평분%실시형광정량취합매련반응%조직심편
Dual specificity phosphatase 5%Prostatic hyperplasia%Prostate cancer%Gleason score%RT-qPCR%Tissue microarray
目的:前期研究发现双特异性磷酸酶5(DUSP5)基因在良性前列腺组织和前列腺癌组织中存在差异性表达,但DUSP5基因的表达与前列腺癌疾病的临床病理相关性尚无统计研究。本次研究检测DUSP5在良性前列腺增生和前列腺癌中的表达,分析其表达水平与临床病理特征的关系。方法通过RT-qPCR检测DUSP5在前列腺癌、前列腺增生组织中DUSP5基因的表达情况;免疫组化检测前列腺癌、前列腺增生标本中DUSP5蛋白的表达。分析DUSP5的表达水平与临床病理特征的关系。结果前列腺癌患者组织中DUSP5基因表达显著下调,DUSP5蛋白表达下调与肿瘤临床分期(≤T2期 vs.>T2期:6.43±0.96 vs.5.10±0.70,P<0.01)、Gleason评分(GS<7 vs. GS≥7:6.37±0.78 vs.5.04±0.57,P<0.01)显著相关。结论 DUSP5蛋白在前列腺癌组织中表达下调,检测DUSP5表达水平可协助判断前列腺癌分化程度并评估预后。
目的:前期研究髮現雙特異性燐痠酶5(DUSP5)基因在良性前列腺組織和前列腺癌組織中存在差異性錶達,但DUSP5基因的錶達與前列腺癌疾病的臨床病理相關性尚無統計研究。本次研究檢測DUSP5在良性前列腺增生和前列腺癌中的錶達,分析其錶達水平與臨床病理特徵的關繫。方法通過RT-qPCR檢測DUSP5在前列腺癌、前列腺增生組織中DUSP5基因的錶達情況;免疫組化檢測前列腺癌、前列腺增生標本中DUSP5蛋白的錶達。分析DUSP5的錶達水平與臨床病理特徵的關繫。結果前列腺癌患者組織中DUSP5基因錶達顯著下調,DUSP5蛋白錶達下調與腫瘤臨床分期(≤T2期 vs.>T2期:6.43±0.96 vs.5.10±0.70,P<0.01)、Gleason評分(GS<7 vs. GS≥7:6.37±0.78 vs.5.04±0.57,P<0.01)顯著相關。結論 DUSP5蛋白在前列腺癌組織中錶達下調,檢測DUSP5錶達水平可協助判斷前列腺癌分化程度併評估預後。
목적:전기연구발현쌍특이성린산매5(DUSP5)기인재량성전렬선조직화전렬선암조직중존재차이성표체,단DUSP5기인적표체여전렬선암질병적림상병리상관성상무통계연구。본차연구검측DUSP5재량성전렬선증생화전렬선암중적표체,분석기표체수평여림상병리특정적관계。방법통과RT-qPCR검측DUSP5재전렬선암、전렬선증생조직중DUSP5기인적표체정황;면역조화검측전렬선암、전렬선증생표본중DUSP5단백적표체。분석DUSP5적표체수평여림상병리특정적관계。결과전렬선암환자조직중DUSP5기인표체현저하조,DUSP5단백표체하조여종류림상분기(≤T2기 vs.>T2기:6.43±0.96 vs.5.10±0.70,P<0.01)、Gleason평분(GS<7 vs. GS≥7:6.37±0.78 vs.5.04±0.57,P<0.01)현저상관。결론 DUSP5단백재전렬선암조직중표체하조,검측DUSP5표체수평가협조판단전렬선암분화정도병평고예후。
Objective To study the expression and significances of DUSP5 in benign prostate hyperplasia (BPH) tissues and prostate cancer tissues, and to illustrate the correlations with clinical significances. Methods RT-qPCR was used to detect DUSP5 protein in prostate cancer tissue and BPH tissue, immunohistochemical method was used to detect DUSP5 in prostate cancer tissue and BPH tissue, and evaluated the correlations with clinical significances of prostate cancer. Results The expression of DUSP5 mRNA was significantly down-regulated in prostate cancer tissues. The expression level of DUSP5 was statistically significant correlated with clinical stage, Gleason score. Conclusion Our study showed the expression of DUSP5 had down-expression changed trend, suggesting the low level of DUSP5 may help to diagnosis pathologic grade and predict the prognosis of prostate cancer.