CAJ | 학술논문

目的：比较附子不同炮制品（刨附片、炮天雄、黑顺片）对比格犬的心脏急性毒性的影响。方法：比格犬16只，随机分为空白对照组、刨附片组、炮天雄组、黑顺片组，按照4g 生药／kg 灌胃比格犬浓缩液，检测灌胃前和灌胃后1h，1d、3d、7d 和14d 后比格犬体重、体温变化和心电图心率变化，并测定血液中乳酸脱氢酶（LDH）和肌酸激酶同工酶（CK －MB）的含量。结果：给药后1h 内黑顺片组犬出现呕吐，其余组未观察到症状；给药后14d 内比格犬体重、体温正常，给药组乳酸脱氢酶和肌酸激酶同工酶含量，心电图心率与空白组相比，差异无统计学意义（P ＞0.05）。结论：刨附片，炮天雄，黑顺片水煎液按照4g 生药／kg 给犬灌胃，没有明显心脏毒性。
목적：비교부자불동포제품（포부편、포천웅、흑순편）대비격견적심장급성독성적영향。방법：비격견16지，수궤분위공백대조조、포부편조、포천웅조、흑순편조，안조4g 생약／kg 관위비격견농축액，검측관위전화관위후1h，1d、3d、7d 화14d 후비격견체중、체온변화화심전도심솔변화，병측정혈액중유산탈경매（LDH）화기산격매동공매（CK －MB）적함량。결과：급약후1h 내흑순편조견출현구토，기여조미관찰도증상；급약후14d 내비격견체중、체온정상，급약조유산탈경매화기산격매동공매함량，심전도심솔여공백조상비，차이무통계학의의（P ＞0.05）。결론：포부편，포천웅，흑순편수전액안조4g 생약／kg 급견관위，몰유명현심장독성。
Objective To investigate and compare the different processed Aconitum carmichaeli (Paofupian,PaoTianxiong,He-ishunpian)for acute cardiac toxicity in beagle dogs.Methods sixteen Beagle dogs ,randomly divided into control group,Paofupian group,PaoTianxiong group,Heishunpian group,according to the 4 g crude drug /kg gavaging to Beagles,observe fourteen days,and detect the weight,temperature changing and ECG heart rate and blood lactate measurements dehydrogenase and creatine kinase MB be-fore administration and at one hour、one day 、three day、seven day、fourteen day after administration.Results within one hour after administration ,heishunpian group dogs bagan to vomite,the symptoms were not observed in other groups;fourteen days after admin-istration Beagle dogs’s weight,temperature are normal,comparing the administration groups to the control group,the lactate dehy-drogenase and creatine kinase isoenzyme content,ECG heart rate have no significant difference.Conclusion the different processed Ac-onitum carmichaeli (Paofupian,PaoTianxiong,Heishunpian)decoctions according 4g /kg orally to fill beagle dog’s stomach,have no significant cardiac toxicity.