中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
25期
47-49
,共3页
替米沙坦%高血压%疗效%安全性%不同时间
替米沙坦%高血壓%療效%安全性%不同時間
체미사탄%고혈압%료효%안전성%불동시간
Telmisartan%Hypertension%Efficacy%Safety%Different times
目的：探究与分析不同时间段给予替米沙坦治疗高血压的临床疗效及安全性。方法：选取本院2012年12月-2014年12月收治的60例高血压患者，采取随机数字表法分为早间服药组与晚间服药组，每组各30例，早间服药组于每天早8∶00点服用替米沙坦，晚间服药组于每天晚20∶00点服用替米沙坦，对比两组患者的临床疗效。结果：早间服药组总有效率为90.00%，晚间服药组总有效率为93.33%，两组比较差异无统计学意义（χ2=1.78，P>0.05）。早间服药组与晚间服药组白天收缩压与舒张压平均值比较，差异无统计学意义（P>0.05）；但夜间比较差异有统计学意义（P<0.05）；两组24 h收缩压与舒张压平均值比较，差异亦无统计学意义（P>0.05）。早间服药组恶心、头晕、头痛发生率分别为10.00%、16.67%、13.33%，晚间服药组恶心、头晕、头痛发生率分别为6.67%、13.33%、10.00%，两组比较差异无统计学意义（P>0.05）。结论：两种服用方法均可对高血压患者的血压产生影响，但晚间服药疗效明显优于早间服药，值得推广与应用。
目的：探究與分析不同時間段給予替米沙坦治療高血壓的臨床療效及安全性。方法：選取本院2012年12月-2014年12月收治的60例高血壓患者，採取隨機數字錶法分為早間服藥組與晚間服藥組，每組各30例，早間服藥組于每天早8∶00點服用替米沙坦，晚間服藥組于每天晚20∶00點服用替米沙坦，對比兩組患者的臨床療效。結果：早間服藥組總有效率為90.00%，晚間服藥組總有效率為93.33%，兩組比較差異無統計學意義（χ2=1.78，P>0.05）。早間服藥組與晚間服藥組白天收縮壓與舒張壓平均值比較，差異無統計學意義（P>0.05）；但夜間比較差異有統計學意義（P<0.05）；兩組24 h收縮壓與舒張壓平均值比較，差異亦無統計學意義（P>0.05）。早間服藥組噁心、頭暈、頭痛髮生率分彆為10.00%、16.67%、13.33%，晚間服藥組噁心、頭暈、頭痛髮生率分彆為6.67%、13.33%、10.00%，兩組比較差異無統計學意義（P>0.05）。結論：兩種服用方法均可對高血壓患者的血壓產生影響，但晚間服藥療效明顯優于早間服藥，值得推廣與應用。
목적：탐구여분석불동시간단급여체미사탄치료고혈압적림상료효급안전성。방법：선취본원2012년12월-2014년12월수치적60례고혈압환자，채취수궤수자표법분위조간복약조여만간복약조，매조각30례，조간복약조우매천조8∶00점복용체미사탄，만간복약조우매천만20∶00점복용체미사탄，대비량조환자적림상료효。결과：조간복약조총유효솔위90.00%，만간복약조총유효솔위93.33%，량조비교차이무통계학의의（χ2=1.78，P>0.05）。조간복약조여만간복약조백천수축압여서장압평균치비교，차이무통계학의의（P>0.05）；단야간비교차이유통계학의의（P<0.05）；량조24 h수축압여서장압평균치비교，차이역무통계학의의（P>0.05）。조간복약조악심、두훈、두통발생솔분별위10.00%、16.67%、13.33%，만간복약조악심、두훈、두통발생솔분별위6.67%、13.33%、10.00%，량조비교차이무통계학의의（P>0.05）。결론：량충복용방법균가대고혈압환자적혈압산생영향，단만간복약료효명현우우조간복약，치득추엄여응용。
Objective: To explore and analyze different time periods given telmisartan treatment of hypertension clinical efficacy and safety.Method: In our hospital from December 2012 to December 2014 60 cases hypertensive patients were selected and divided into morning medication group and evening medication group, 30 cases in each group. Morning medication group took telmisartan at 8∶00 am, and evening medication group took telmisartan at 8∶00 pm. To compare curative effect between the two groups.Result: The total effective rate of the morning medication group was90.00%, and that of the evening medication group was 93.33%, with no significant difference between the two groups ( χ2=1.78,P>0.05). Systolic and diastolic blood pressure between the two groups showed no significant difference during daytime and 24 h, but had at night. Nausea, dizziness, headache rate of the morning medication group was 10.00%, 16.67%, 13.33%, and that of the evening medication group was 6.67%, 13.33%, 10.00%, there was no significant difference between the two groups (P>0.05).Conclusion: Both methods can take effect on blood pressure in hypertensive patients, but clinical efficacy in the evening for hypertensive patients taking telmisartan was significantly better than the morning medication, worthy of promotion and application.
