CAJ | 학술논문

目的评估霍奇金淋巴瘤患者EB病毒(EBV)感染状态及EBV阳性对患者治疗及预后的影响.方法选取2008年2月至2014年10月中国医学科学院肿瘤医院收治的207例初治霍奇金淋巴瘤患者,统计原位杂交方法检测蜡块中EBV编码的RNA(EBER)或免疫组化方法检测蜡块中潜伏膜蛋白-1(LMP-1)的结果,确定EBV感染状态,分析EBV阳性与临床特征相关性及其对患者预后的影响.结果 207例患者淋巴瘤组织中,共检测出EBV阳性66例,阳性率为31.9％.EBV阳性患者中,男性多见(46/66,69.7％),病理亚型以混合细胞型为主(34/66,51.5％).EBV阳性患者呈年龄双峰分布,分别是在年龄0～15岁和年龄＞ 60岁.全组患者中位随访35个月,EBV阳性患者的总生存时间短于EBV阴性患者(P=0.001),无进展生存时间二者间差异无统计学意义(P =0.763).结论 EBV阳性是霍奇金淋巴瘤患者总生存时间的不良预后因素.
목적 평고곽기금림파류환자EB병독(EBV)감염상태급EBV양성대환자치료급예후적영향.방법 선취2008년2월지2014년10월중국의학과학원종류의원수치적207례초치곽기금림파류환자,통계원위잡교방법검측사괴중EBV편마적RNA(EBER)혹면역조화방법검측사괴중잠복막단백-1(LMP-1)적결과,학정EBV감염상태,분석EBV양성여림상특정상관성급기대환자예후적영향.결과 207례환자림파류조직중,공검측출EBV양성66례,양성솔위31.9％.EBV양성환자중,남성다견(46/66,69.7％),병리아형이혼합세포형위주(34/66,51.5％).EBV양성환자정년령쌍봉분포,분별시재년령0～15세화년령＞ 60세.전조환자중위수방35개월,EBV양성환자적총생존시간단우EBV음성환자(P=0.001),무진전생존시간이자간차이무통계학의의(P =0.763).결론 EBV양성시곽기금림파류환자총생존시간적불량예후인소.
Objective To evaluate the Epstein Barr virus (EBV)positive rate in untreated Hodgkin's lymphoma(HL) and investigate the prognostic significance of EBV status.Methods A total of 207 previously untreated patients with histologically confirmed Hodgkin's lymphoma were enrolled in the study.The EBV infection status was confirmed through examining EBV-RNA (EBER) or EBV latent membrane protein-1.The correlation of clinical features and EBV infection status was analyzed,also the prognostic significance of EBV infection.Results A total of 66 cases were confirmed to be EBV positive Hodgkin's lymphoma(EBV + HL) in all 207 cases,accounting for 31.9％.EBV + HL group had more male patients (46/66,69.7％) and mixed cellularity subtype (34/66,51.5％) than EBV negative Hodgkin's lymphoma(EBV-HL) group.The EBV positive rate had two peaks in age,respectively,in the age of 0-15 year-old and ＞ 60 year-old.During a median follow-up period of 35 months,EBV-HL was significant better than EBV + HL in overall survival(P =0.001),but no significant difference was found in progression-free survival(P =0.763).Conclusion EBV positive is a poor prognostic factor for overall survival time in HL.