CAJ | 학술논문

目的：评价外用0.5％5-氟脲嘧啶（5- Fu）治疗日光性角化病（AK）的疗效及安全性。方法计算机检索Cochrane 图书馆、Medline，Embase，NGC 和 CBM，纳入所有0.5％5- Fu 治疗 AK 的随机对照试验。由2名研究者独立进行质量评估和交叉核对，并采用 RevMan 4.3软件进行统计分析。结果共纳入3篇随机对照试验（RCT），包括528例患者，meta 分析结果显示：疗程1周、2周及4周临床疗效均优于安慰剂，差异有统计学意义（P ＜0.05）；疗程4周的临床疗效优于疗程1周及2周，差异有统计学意义（P ＜0.05）。不良反应主要为局部皮肤刺激，随疗程的延长而增加，但多为轻中度，患者具有较好的耐受性。结论0.5％5-氟脲嘧啶治疗日光性角化病是安全有效的。
목적：평개외용0.5％5-불뇨밀정（5- Fu）치료일광성각화병（AK）적료효급안전성。방법계산궤검색Cochrane 도서관、Medline，Embase，NGC 화 CBM，납입소유0.5％5- Fu 치료 AK 적수궤대조시험。유2명연구자독립진행질량평고화교차핵대，병채용 RevMan 4.3연건진행통계분석。결과공납입3편수궤대조시험（RCT），포괄528례환자，meta 분석결과현시：료정1주、2주급4주림상료효균우우안위제，차이유통계학의의（P ＜0.05）；료정4주적림상료효우우료정1주급2주，차이유통계학의의（P ＜0.05）。불량반응주요위국부피부자격，수료정적연장이증가，단다위경중도，환자구유교호적내수성。결론0.5％5-불뇨밀정치료일광성각화병시안전유효적。
Objective To assess the effect and safety of 0. 5% 5 - flurouracil in the treatment of Actinic keratosis. Methods The Cochrane library,Medline,Embase,NGC and CBM were searched,the randomized controlled trials(RCTs)about 0. 5%5 - flurouracil for the treatment of actinic keratosis all over the world were included. Two reviewers independently screened the studies for eligibility,evaluated the quality with confirmation by cross - checking. The data were inputted and analyzed by Rev-Man 4. 3 software. Results Three RCT studies involving 528 patients met the inclusion criteria. Meta analysis of the treatment of 0. 5% 5 - flurouracil showed treatment applied once daily for 1,2,or 4 weeks was more effective than vehicle control in lesion clearance. And the treatment for 4 weeks was better than one week and two weeks. Commonly reported adverse events were local-ized facial irritation. Most of them were mild or moderate,and most of these patients were able to tolerate it. Conclusion Topi-cal 0. 5% 5 - flurouracil was an effective and safe regimen for the treatment of actinic keratosis.