肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2015年
4期
286-288
,共3页
恶性黑色素瘤%白介素-23%血管内皮生长因子
噁性黑色素瘤%白介素-23%血管內皮生長因子
악성흑색소류%백개소-23%혈관내피생장인자
malignant melanoma%interleukin-23%vascular endothelial growth factor
目的：探讨恶性黑色素瘤患者血清中白介素-23（IL-23）和血管内皮生长因子（VEGF）的水平检测及意义。方法采用酶联免疫吸附试验检测53例恶性黑色素瘤患者和30例普通色素痣患者血清中 IL-23和 VEGF 水平，并分析 IL-23和 VEGF 与黑色素瘤临床病理特征的关系。结果恶性黑色素瘤患者血清中IL-23和 VEGF 水平明显高于普通色素痣患者（P <0.05）。恶性黑色素瘤患者血清中 IL-23和 VEGF 水平与恶性黑色素瘤的临床分期和淋巴结转移与否关系密切（P <0.05）。结论 IL-23和 VEGF 在恶性黑色素瘤患者体内存在高表达，两者联合检测可用于恶性黑色素瘤的病情和预后评估。
目的：探討噁性黑色素瘤患者血清中白介素-23（IL-23）和血管內皮生長因子（VEGF）的水平檢測及意義。方法採用酶聯免疫吸附試驗檢測53例噁性黑色素瘤患者和30例普通色素痣患者血清中 IL-23和 VEGF 水平，併分析 IL-23和 VEGF 與黑色素瘤臨床病理特徵的關繫。結果噁性黑色素瘤患者血清中IL-23和 VEGF 水平明顯高于普通色素痣患者（P <0.05）。噁性黑色素瘤患者血清中 IL-23和 VEGF 水平與噁性黑色素瘤的臨床分期和淋巴結轉移與否關繫密切（P <0.05）。結論 IL-23和 VEGF 在噁性黑色素瘤患者體內存在高錶達，兩者聯閤檢測可用于噁性黑色素瘤的病情和預後評估。
목적：탐토악성흑색소류환자혈청중백개소-23（IL-23）화혈관내피생장인자（VEGF）적수평검측급의의。방법채용매련면역흡부시험검측53례악성흑색소류환자화30례보통색소지환자혈청중 IL-23화 VEGF 수평，병분석 IL-23화 VEGF 여흑색소류림상병리특정적관계。결과악성흑색소류환자혈청중IL-23화 VEGF 수평명현고우보통색소지환자（P <0.05）。악성흑색소류환자혈청중 IL-23화 VEGF 수평여악성흑색소류적림상분기화림파결전이여부관계밀절（P <0.05）。결론 IL-23화 VEGF 재악성흑색소류환자체내존재고표체，량자연합검측가용우악성흑색소류적병정화예후평고。
Objective To investigate the serum interleukin-23(IL-23)and vascular endothelial growth factor (VEGF)levels in the patients with malignant melanoma and their significance. Methods Enzyme linked immu-nosorbent assay was used to detect the serum IL-23 and VEGF levels in the 53 patients with malignant melanoma and the 30 patients with black nevus,and the relationship between IL-23 or VEGF and clinicopathological features were analyzed too. Results The serum IL-23 and VEGF levels in the malignant melanoma group were higher than those in the black nevus group(P < 0. 05). The serum IL-23 and VEGF levels in the malignant melanoma group were related with the clinical stage and lymph node metastasis(P < 0. 05). Conclusion High serum levels of IL-23 and VEGF are observed in the malignant melanoma,associated detection of them can be used to evaluate the malignant melanoma.
