CAJ | 학술논문

目的：研究视黄醇结合蛋白4在妊娠期糖尿病患者和正常孕妇的不同孕周的血清及新生儿脐血中的表达，为妊娠期糖尿病的预测及治疗提供依据。方法：选择2013年1-12月在本院产科产检的妊娠期糖尿病孕妇50例作为试验组，正常孕妇50例作为对照组。用ELISA法检测孕31~33周孕妇血清，37~41周孕妇血清及新生儿脐血血清中视黄醇结合蛋白4的含量。结果：随着孕周的增加视黄醇结合蛋白4增加，不同时间段比较差异均有统计学意义（P<0.001）；试验组血清视黄醇结合蛋白4在不同时间段均高于对照组，比较差异均有统计学意义（P<0.001）；两组血清视黄醇结合蛋白4的差值在不同采血时段逐渐增加，比较差异有统计学意义（P<0.001）；试验组视黄醇结合蛋白4增加的幅度大于对照组，比较差异均有统计学意义（P<0.001）；试验组血清视黄醇结合蛋白4与FBG、FINS、HOMA-IR呈正相关（P<0.001）。结论：可考虑依据血清视黄醇结合蛋白4水平对妊娠期糖尿病进行预测及评估，并指导GDM的治疗。
목적：연구시황순결합단백4재임신기당뇨병환자화정상잉부적불동잉주적혈청급신생인제혈중적표체，위임신기당뇨병적예측급치료제공의거。방법：선택2013년1-12월재본원산과산검적임신기당뇨병잉부50례작위시험조，정상잉부50례작위대조조。용ELISA법검측잉31~33주잉부혈청，37~41주잉부혈청급신생인제혈혈청중시황순결합단백4적함량。결과：수착잉주적증가시황순결합단백4증가，불동시간단비교차이균유통계학의의（P<0.001）；시험조혈청시황순결합단백4재불동시간단균고우대조조，비교차이균유통계학의의（P<0.001）；량조혈청시황순결합단백4적차치재불동채혈시단축점증가，비교차이유통계학의의（P<0.001）；시험조시황순결합단백4증가적폭도대우대조조，비교차이균유통계학의의（P<0.001）；시험조혈청시황순결합단백4여FBG、FINS、HOMA-IR정정상관（P<0.001）。결론：가고필의거혈청시황순결합단백4수평대임신기당뇨병진행예측급평고，병지도GDM적치료。
Objective:To study the expression of retinol-binding protein 4 in neonates umbilical blood and serum of gestational diabetics and normal pregnant women during different gestational weeks in order to provide basis for the estimation and treatment of gestational diabetes mellitus(GDM).Method:Among the pregnant women who received antenatal care in our hospital from January 2013 to December 2013,50 pregnant women with GDM were selected as the experimental group,50 normal pregnant women were selected as the control group.The retinol-binding protein 4 levels in serum of neonates umbilical cord and pregnancy of 31 to 33 weeks and 37 to 41 weeks were detected through ELISA method.Result:The retinol-binding protein 4 was increased according with the increase of gestational weeks, the differences of it in different times were statistically significant(P<0.001). The retinol-binding protein 4 of the experimental group in different times was higher than that of the control group,the difference was statistically significant (P<0.001).The difference values in retinol-binding protein 4 of the two groups were increased with the time, the differences were statistically significant(P<0.001).The ranges of retinol-binding protein 4 in the experimental group were greater than those in the control group, the differences were statistically significant(P<0.001).The retinol-binding protein 4 of the experimental group had positive correlations with FBG,FINS and HOMA-IR(P<0.001). Conclusion:Retinol-binding protein 4 levels may use as the basis for the prediction and assessment of GDM and as the guidelines for the treatment of gestational diabetes mellitus.