CAJ | 학술논문

目的：观察小剂量米氮平联合益心舒胶囊治疗脑卒中后抑郁（ PsD）对患者血清细胞因子的影响。方法将206例PsD患者随机分为观察组和对照组各103例。观察组给予小剂量米氮平联合益心舒胶囊治疗，对照组单纯给予益心舒胶囊治疗。治疗后比较2组患者的临床疗效，治疗前后比较2组患者血清细胞因子水平的变化，包括血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）。结果治疗后观察组患者的治疗总有效率为93.2%高于对照组的78.6%；治疗后2组患者的IL-1β、IL-6、TNF-α水平均低于治疗前，且观察组低于对照组，差异均有统计学意义（ P﹤0.05）。结论小剂量米氮平联合益心舒胶囊治疗PsD效果较好，可显著降低血清细胞因子水平，可推广应用。
목적：관찰소제량미담평연합익심서효낭치료뇌졸중후억욱（ PsD）대환자혈청세포인자적영향。방법장206례PsD환자수궤분위관찰조화대조조각103례。관찰조급여소제량미담평연합익심서효낭치료，대조조단순급여익심서효낭치료。치료후비교2조환자적림상료효，치료전후비교2조환자혈청세포인자수평적변화，포괄혈청백세포개소-1β（IL-1β）、백세포개소-6（IL-6）、종류배사인자-α（TNF-α）。결과치료후관찰조환자적치료총유효솔위93.2%고우대조조적78.6%；치료후2조환자적IL-1β、IL-6、TNF-α수평균저우치료전，차관찰조저우대조조，차이균유통계학의의（ P﹤0.05）。결론소제량미담평연합익심서효낭치료PsD효과교호，가현저강저혈청세포인자수평，가추엄응용。
Objective To observe the influences of small doses mirtazapine combined with yixinshu capsule in treat-ment of post-stroke depression( PsD)on serum cytokines. Methods 206 cases of patients with PsD were randomly divided into observation group and control group,each of 103 cases. Observation group were given with small doses of mirtazapine com-bined with yixinshu capsule. Control group were given yixinshu capsule. After the treatment compared the clinical efficacy of two groups. Before and after treatment compared the serum cytokine levels change of two groups,including serum interleukin -1β(IL-1β),interleukin -6(IL-6),tumor necrosis factor-α(TNF-α). Results After treatment,the total effective rate of ob-servation group was 93. 2% higher than 78. 6% of control group;After treatment,the serum IL-1β,IL-6,TNF-α levels of two groups were lower than before treatment,and observation group were lower than control group,the differences were statistically significant(P ﹤0. 05). Conclusion small doses mirtazapine combined with yixinshu capsule in treatment of PsD has a better effect,can significantly reduce serum cytokines levels,it can be widely applied.