CAJ | 학술논문

目的：观察大剂量纳洛酮联合奥扎格雷对急性脑梗死血脂及生活质量的影响。方法选取该院2013年1月-2014年12月收治的急性脑梗死患者210例，随机分为观察组和对照组各105例。2组均根据病情予以降血糖、调血压、控制颅内压等对症治疗。在此基础上，观察组给予大剂量纳洛酮联合奥扎格雷治疗；对照组给予常规剂量纳洛酮联合奥扎格雷治疗。治疗前后观察2组患者的血脂及生活质量。结果治疗后2组患者的血清三酰甘油（ TC）、总胆固醇（ TG）水平及低密度脂蛋白胆固醇（ LDL-C）低于治疗前，高密度脂蛋白胆固醇（ HDL-C）水平高于治疗前，神经功能缺损程度评分（ NDs）和日常生活能力评分（ ADL）均低于治疗前，且观察组变化幅度大于对照组，差异均有统计学意义（ P﹤0.05）。结论大剂量纳洛酮联合奥扎格雷治疗急性脑梗死可改善患者血脂水平，提高患者的生活质量，值得临床推广应用。
목적：관찰대제량납락동연합오찰격뢰대급성뇌경사혈지급생활질량적영향。방법선취해원2013년1월-2014년12월수치적급성뇌경사환자210례，수궤분위관찰조화대조조각105례。2조균근거병정여이강혈당、조혈압、공제로내압등대증치료。재차기출상，관찰조급여대제량납락동연합오찰격뢰치료；대조조급여상규제량납락동연합오찰격뢰치료。치료전후관찰2조환자적혈지급생활질량。결과치료후2조환자적혈청삼선감유（ TC）、총담고순（ TG）수평급저밀도지단백담고순（ LDL-C）저우치료전，고밀도지단백담고순（ HDL-C）수평고우치료전，신경공능결손정도평분（ NDs）화일상생활능력평분（ ADL）균저우치료전，차관찰조변화폭도대우대조조，차이균유통계학의의（ P﹤0.05）。결론대제량납락동연합오찰격뢰치료급성뇌경사가개선환자혈지수평，제고환자적생활질량，치득림상추엄응용。
Objective To observe the influence of large doses naloxone combined with ozagrel in treatment of acute cerebral blood lipids and life qualityMethods 210 cases of patients with acute cerebral infarction,selected in the hospital from January 2013 to December 2014,were randomly divided into observation group and control group,each of 105 cases. Two groups according to the disease gave lowering blood sugar,blood pressure adjustment,control of intracranial pressure and other symptomatic treatment. On this basis,observation group were given with large doses naloxone combined with ozagrel;control group received conventional doses naloxone combined with ozagrel. Observed the lipid and life quality in two groups of patients. before and after treatment. Results After treatment,the two groups of patients with serum triglyceride( TC),total cholesterol (TG)levels and low density lipoprotein cholesterol(LDL-C)were lower than those before treatment,high-density lipoprotein cholesterol( HDL-C)levels was higher than before treatment,nerve function impairment score( NDs)and activities of daily liv-ing score( ADL)were lower than before treatment,and changes magnitude of observation group were greater than control group, the differences were statistically significant(P﹤0. 05). Conclusion Large doses naloxone combined with ozagrel in treatment of acute cerebral infarction patients can improve blood lipid levels,improve the quality of life of patients,worthy of clinical ap-plication.