肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2015年
4期
289-290
,共2页
结肠腺癌%基质金属蛋白酶 - 2%基质金属蛋白酶 - 9%免疫组化
結腸腺癌%基質金屬蛋白酶 - 2%基質金屬蛋白酶 - 9%免疫組化
결장선암%기질금속단백매 - 2%기질금속단백매 - 9%면역조화
colon adenocarcinoma%matrix metalloproteinase-2%matrix metalloproteinase-9%immunohistochemistry
目的：探讨结肠腺癌组织中基质金属蛋白酶-2（MMP-2）和 MMP-9的表达及其临床意义。方法采用免疫组化 S-P 法检测93例结肠腺癌和30例正常结肠组织中 MMP-2和 MMP-9的表达，并分析两者与结肠腺癌临床病理参数的关系。结果结肠腺癌组织中 MMP-2和 MMP-9的阳性率分别为76.34%和77.42%，均高于正常结肠组织的16.67%和16.67%（P <0.05）。结肠癌组织中 MMP-2和 MMP-9的表达与肿瘤的分化程度、淋巴结转移、TNM 分期均有关（P <0.05）。结论 MMP-2和 MMP-9高表达能够促进结肠腺癌的发生和进展。
目的：探討結腸腺癌組織中基質金屬蛋白酶-2（MMP-2）和 MMP-9的錶達及其臨床意義。方法採用免疫組化 S-P 法檢測93例結腸腺癌和30例正常結腸組織中 MMP-2和 MMP-9的錶達，併分析兩者與結腸腺癌臨床病理參數的關繫。結果結腸腺癌組織中 MMP-2和 MMP-9的暘性率分彆為76.34%和77.42%，均高于正常結腸組織的16.67%和16.67%（P <0.05）。結腸癌組織中 MMP-2和 MMP-9的錶達與腫瘤的分化程度、淋巴結轉移、TNM 分期均有關（P <0.05）。結論 MMP-2和 MMP-9高錶達能夠促進結腸腺癌的髮生和進展。
목적：탐토결장선암조직중기질금속단백매-2（MMP-2）화 MMP-9적표체급기림상의의。방법채용면역조화 S-P 법검측93례결장선암화30례정상결장조직중 MMP-2화 MMP-9적표체，병분석량자여결장선암림상병리삼수적관계。결과결장선암조직중 MMP-2화 MMP-9적양성솔분별위76.34%화77.42%，균고우정상결장조직적16.67%화16.67%（P <0.05）。결장암조직중 MMP-2화 MMP-9적표체여종류적분화정도、림파결전이、TNM 분기균유관（P <0.05）。결론 MMP-2화 MMP-9고표체능구촉진결장선암적발생화진전。
Objective To investigate the expressions of matrix metalloproteinase-2(MMP-2)and MMP-9 in the colon adenocarcinoma and their clinical significance. Methods Immunohistochemistry method was used to detect the expressions of MMP-2 and MMP-9 in the 93 patients with colon adenocarcinoma and 30 cases of colon normal mucosa,and the relationship between MMP-2 or MMP-9 and clinicopathological parameters were analyzed too. Re-sults The positive rates of MMP-2 and MMP-9(76. 34% and 77. 42% )in the colon adenocarcinoma were signifi-cant higher than those(16. 67% and 16. 67% )in the normal colon mucosa(P < 0. 05). The expressions of MMP-2 and MMP-9 in the colon adenocarcinoma were related to the pathological grade,lymph node metastasis and TNM staging(P < 0. 05). Conclusion High expressions of MMP-2 and MMP-9 can promote the occurrence and devel-opment of colon adenocarcinoma.
