医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2015年
9期
1155-1157
,共3页
钩藤总碱%高血压%损伤,靶器官%动脉压力感受反射
鉤籐總堿%高血壓%損傷,靶器官%動脈壓力感受反射
구등총감%고혈압%손상,파기관%동맥압력감수반사
Total alkaloids from Rhynchophylline%Hypertension%Injury,target organs%Baroreflex
目的：观察钩藤总碱对高血压靶器官的作用。方法自发性高血压模型大鼠40只,随机分为4组,正常对照组、天麻钩藤饮组、钩藤总碱小剂量组和钩藤总碱大剂量组,每组10只,分别口服普通饲料、天麻钩藤饮颗粒(750 mg?d－1)、钩藤总碱2.5,15.0 mg?d－1。采用改良的 Smyth 方法测定各组大鼠的动脉压力感受反射功能,20周后,取大鼠心、脑、肾,进行组织学观察。结果正常对照组、天麻钩藤饮组、钩藤总碱小剂量组和钩藤总碱大剂量组第16周动脉压力感受反射敏感性分别为(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms?mmHg－1。正常对照组大鼠动脉压力感受反射功能降低,而其他各用药组没有降低；给药组大鼠可见心肌结构显著优于正常对照组,脑组织和肾小球结构未见显著改善。结论钩藤总碱对高血压靶器官心脏有保护作用。
目的：觀察鉤籐總堿對高血壓靶器官的作用。方法自髮性高血壓模型大鼠40隻,隨機分為4組,正常對照組、天痳鉤籐飲組、鉤籐總堿小劑量組和鉤籐總堿大劑量組,每組10隻,分彆口服普通飼料、天痳鉤籐飲顆粒(750 mg?d－1)、鉤籐總堿2.5,15.0 mg?d－1。採用改良的 Smyth 方法測定各組大鼠的動脈壓力感受反射功能,20週後,取大鼠心、腦、腎,進行組織學觀察。結果正常對照組、天痳鉤籐飲組、鉤籐總堿小劑量組和鉤籐總堿大劑量組第16週動脈壓力感受反射敏感性分彆為(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms?mmHg－1。正常對照組大鼠動脈壓力感受反射功能降低,而其他各用藥組沒有降低；給藥組大鼠可見心肌結構顯著優于正常對照組,腦組織和腎小毬結構未見顯著改善。結論鉤籐總堿對高血壓靶器官心髒有保護作用。
목적：관찰구등총감대고혈압파기관적작용。방법자발성고혈압모형대서40지,수궤분위4조,정상대조조、천마구등음조、구등총감소제량조화구등총감대제량조,매조10지,분별구복보통사료、천마구등음과립(750 mg?d－1)、구등총감2.5,15.0 mg?d－1。채용개량적 Smyth 방법측정각조대서적동맥압력감수반사공능,20주후,취대서심、뇌、신,진행조직학관찰。결과정상대조조、천마구등음조、구등총감소제량조화구등총감대제량조제16주동맥압력감수반사민감성분별위(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms?mmHg－1。정상대조조대서동맥압력감수반사공능강저,이기타각용약조몰유강저；급약조대서가견심기결구현저우우정상대조조,뇌조직화신소구결구미견현저개선。결론구등총감대고혈압파기관심장유보호작용。
Objective To investigate the effect of total alkaloids from Rhynchophylline on hypertensive target organs. Methods 40 spontaneous hypertensive rats (SHRs) were divided into 4 groups as follows: normal control group,positive control with Tianma Goutengyin granule at 750 mg?d-1 ,total alkaloids from Rhynchophylline at 2.5 mg?day-1 as low dosage,and at 15.0 mg?d-1 as high dosage.All the rats were fed up for 20 weeks,and baroreflex sensitivity (BRS,in ms?mmHg-1)was determined by revised Smyth’s method.Heart,brain and kidney of the rats were sectioned for histological analysis at the end of 20th week. Results In sixteenth weeks,BRS of positive control,Tianma Goutengyin granule group,total alkaloids at low dosage and high dosage were(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms?mmHg-1,respectively.BRS in SHR was not decreased except in the positive control.The treatment groups were superior to the normal control group in structure of heart,but not in the brain and kidney of the rats. Conclusion Total alkaloids from Rhynchophyllinecould protect heart from hypertensive injury.
