CAJ | 학술논문

目的：探讨加味玉屏风散对变应性鼻炎(allergic Rhinitis，AR)大鼠模型中免疫球蛋白E（IgE）的影响。方法采用卵清蛋白对SD雌性大鼠做全身致敏与局部攻击方法制作变应性鼻炎大鼠模型，给予加味玉屏风散灌胃后，心脏取血行ELISA法检测免疫球蛋白E。结果4组间比较,模型组中血浆免疫球蛋白E含量显著高于正常组(P<0.01)；2个治疗组中免疫球蛋白E的含量明显低于模型组，差异有统计学意义（P<0.01）。2个治疗组间免疫球蛋白比较，差异无统计学意义。结论加味玉屏风散能使变应性鼻炎大鼠模型中免疫球蛋白E减少，可起到抗过敏反应的作用。
목적：탐토가미옥병풍산대변응성비염(allergic Rhinitis，AR)대서모형중면역구단백E（IgE）적영향。방법채용란청단백대SD자성대서주전신치민여국부공격방법제작변응성비염대서모형，급여가미옥병풍산관위후，심장취혈행ELISA법검측면역구단백E。결과4조간비교,모형조중혈장면역구단백E함량현저고우정상조(P<0.01)；2개치료조중면역구단백E적함량명현저우모형조，차이유통계학의의（P<0.01）。2개치료조간면역구단백비교，차이무통계학의의。결론가미옥병풍산능사변응성비염대서모형중면역구단백E감소，가기도항과민반응적작용。
Objective To study the effects of Modified Yuping Feng San on Immunoglobulin E (IgE) of rat model with allergic rhinitis (AR). Methods Rat model of allergic rhinitis was produced by using ovalbumin on SD female rats. ELISA was used to detect heart blood immunoglobulin E after the model rats were given orally Modified Yuping Feng San.Results When compared between these four groups, the proportion of IgE in model group was significantly higher than normal group (P<0.01). The counts of IgE in two treatment groups were less than model group, the difference was statistically significant (P<0.01).Conclusion Modified Yuping Feng San can reduce IgE counts in the AR rat model, may play a role in anti-allergic.