CAJ | 학술논문

目的：观察丹红注射液联合前列地尔治疗早期糖尿病肾病（DN）的临床疗效。方法：从2013年3月-2014年7月在我科住院治疗的患者中选取符合诊断标准的病例48例，在良好控制血糖的基础上将其随机分为两组，其中对照组24例使用前列地尔注射液，治疗组24例使用丹红注射液联合前列地尔注射液，疗程为2周。治疗结束后观察两组患者治疗前后24h的尿蛋白定量、尿白蛋白排泄率变化。结果：治疗后两组患者24h 尿蛋白定量、尿白蛋白排泄率均有所下降，治疗组下降的更为显著（P<0.05）。治疗组的总有效率为87.5%，对照组的总有效率为75%，治疗组优于对照组（P<0.05）。结论：丹红注射液联合前列地尔治疗早期糖尿病肾病有较好的疗效。
목적：관찰단홍주사액연합전렬지이치료조기당뇨병신병（DN）적림상료효。방법：종2013년3월-2014년7월재아과주원치료적환자중선취부합진단표준적병례48례，재량호공제혈당적기출상장기수궤분위량조，기중대조조24례사용전렬지이주사액，치료조24례사용단홍주사액연합전렬지이주사액，료정위2주。치료결속후관찰량조환자치료전후24h적뇨단백정량、뇨백단백배설솔변화。결과：치료후량조환자24h 뇨단백정량、뇨백단백배설솔균유소하강，치료조하강적경위현저（P<0.05）。치료조적총유효솔위87.5%，대조조적총유효솔위75%，치료조우우대조조（P<0.05）。결론：단홍주사액연합전렬지이치료조기당뇨병신병유교호적료효。
Objective:To investigate clinical efficacy of the Danhong injection plus alprostadil on diabetic nephropathy. Methods: 48 patients were randomly divided into two groups. The control group of 24 cases were treated with the alprostadil injection. The treatment group of 24 cases were treated with the Danhong injection plus alprostadil injection, for two weeks. After treatment, 24h urine total protein and changes in urinary albumin excretion rate were observed. Results: After treatment, 24h urinary albumin, urinary albumin excretion rate were decreased in each group. The treatment group decreased more significantly (P<0.05). The total efficiency was 87.5% in the treatment group. The total efficiency was 75% in the control group. There was a significance difference between two groups (P<0.05). Conclusion: Treating diabetic nephropathy by the Danhong injection plus alprostadil can have a better effect.