中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2015年
8期
609-611
,共3页
李红军%曹永芝%刘宝南%冯玲吉%李鹏
李紅軍%曹永芝%劉寶南%馮玲吉%李鵬
리홍군%조영지%류보남%풍령길%리붕
姜黄素%百草枯%脂质过氧化
薑黃素%百草枯%脂質過氧化
강황소%백초고%지질과양화
Curcumin%Paraquat%Lipid peroxidation
目的 观察姜黄素治疗条件下百草枯(PQ)中毒大鼠脂质过氧化的变化.方法 将清洁级8周龄Wistar雄性大鼠50只随机分为高剂量姜黄素+常规治疗组、低剂量姜黄素+常规治疗组、单独高剂量姜黄素治疗组、PQ单纯染毒组和空白对照组,分别在染毒后第1、3、7、14天和第21天检测大鼠血清中谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量.结果 与空白对照组相比,高剂量姜黄素+常规治疗组、低剂量姜黄素+常规治疗组、单独高剂量姜黄素治疗组、PQ单独染毒组大鼠MDA含量明显升高,而SOD、GSH-Px和CAT活力明显降低,差异均有统计学意义(P＜0.05).高剂量姜黄素+常规治疗组、低剂量姜黄素+常规治疗组和单独高剂量姜黄素治疗组与PQ单独染毒组比较,MDA含量降低,SOD、GSH-Px、CAT活力升高,差异有统计学意义(P＜0.05).高剂量姜黄素+常规治疗组脂质过氧化指标改善最明显.结论 姜黄素可明显降低大鼠血清脂质过氧化水平,抑制并延缓机体损伤的发生发展.
目的 觀察薑黃素治療條件下百草枯(PQ)中毒大鼠脂質過氧化的變化.方法 將清潔級8週齡Wistar雄性大鼠50隻隨機分為高劑量薑黃素+常規治療組、低劑量薑黃素+常規治療組、單獨高劑量薑黃素治療組、PQ單純染毒組和空白對照組,分彆在染毒後第1、3、7、14天和第21天檢測大鼠血清中穀胱甘肽過氧化物酶(GSH-Px)、過氧化氫酶(CAT)、超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量.結果 與空白對照組相比,高劑量薑黃素+常規治療組、低劑量薑黃素+常規治療組、單獨高劑量薑黃素治療組、PQ單獨染毒組大鼠MDA含量明顯升高,而SOD、GSH-Px和CAT活力明顯降低,差異均有統計學意義(P＜0.05).高劑量薑黃素+常規治療組、低劑量薑黃素+常規治療組和單獨高劑量薑黃素治療組與PQ單獨染毒組比較,MDA含量降低,SOD、GSH-Px、CAT活力升高,差異有統計學意義(P＜0.05).高劑量薑黃素+常規治療組脂質過氧化指標改善最明顯.結論 薑黃素可明顯降低大鼠血清脂質過氧化水平,抑製併延緩機體損傷的髮生髮展.
목적 관찰강황소치료조건하백초고(PQ)중독대서지질과양화적변화.방법 장청길급8주령Wistar웅성대서50지수궤분위고제량강황소+상규치료조、저제량강황소+상규치료조、단독고제량강황소치료조、PQ단순염독조화공백대조조,분별재염독후제1、3、7、14천화제21천검측대서혈청중곡광감태과양화물매(GSH-Px)、과양화경매(CAT)、초양화물기화매(SOD)활력화병이철(MDA)함량.결과 여공백대조조상비,고제량강황소+상규치료조、저제량강황소+상규치료조、단독고제량강황소치료조、PQ단독염독조대서MDA함량명현승고,이SOD、GSH-Px화CAT활력명현강저,차이균유통계학의의(P＜0.05).고제량강황소+상규치료조、저제량강황소+상규치료조화단독고제량강황소치료조여PQ단독염독조비교,MDA함량강저,SOD、GSH-Px、CAT활력승고,차이유통계학의의(P＜0.05).고제량강황소+상규치료조지질과양화지표개선최명현.결론 강황소가명현강저대서혈청지질과양화수평,억제병연완궤체손상적발생발전.
Objective To explore the pathogenesis of paraquat poisoning and observe the change in lipid peroxidation of rats treated with different doses of curcumin.Methods A total of 50 8-week-old male Wistar rats (clean grade) were randomly divided into high-dose curcumin plus conventional treatment group,low-dose curcumin plus conventional treatment group,high-dose curcumin treatment group,poisoned group,and blank control group.Glutathione peroxidase (GSH-Px),catalase (CAT),superoxide dismutase (SOD),and malondialdehyde (MDA) levels in rat serum were measured at 1,3,7,14,and 21 d post paraquat injection.Results Compared with the blank control group,other groups had significantly higher MDA levels but lower SOD,GSH-PX,and CAT activities.The high-dose,low-dose curcumin plus conventional treatment,and high-dose curcumin treatment groups had significantly lower serum lipid peroxidation levels compared with the poisoned group and among them the high-dose curcumin plus conventional treatment group had the most significant improvement.Conclusion Curcumin can significantly decrease serum lipid peroxidation level in rats and inhibit and delay the occurrence and progression of the damage to the body.
