中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2015年
8期
635-640
,共6页
张斌(综述)%汪昱(审校)
張斌(綜述)%汪昱(審校)
장빈(종술)%왕욱(심교)
新辅助治疗%手术时机%局部进展期直肠癌
新輔助治療%手術時機%跼部進展期直腸癌
신보조치료%수술시궤%국부진전기직장암
Neoadjuvant chemoradiotherapy%Operation time interval%Locally progressed rectal carcinoma
进展期直肠癌行新辅助放化疗(neoadjuvant chemoradiotherapy,nCRT)后的延期手术可以增加根治切除机会,降低局部复发,同时改善患者总体生存率。常规的术前放化疗与手术之间的时间间隔为4~6周,延长手术时间间隔可以增加肿瘤退缩的程度,但是超过6~8周也可能会增加手术难度、手术并发症发生率及肿瘤复发或转移的风险。回顾分析相关文献,从肿瘤缓解率、预后、患病率和死亡率等方面对nCRT后延期手术时机选择对预后影响的研究进展进行综述。
進展期直腸癌行新輔助放化療(neoadjuvant chemoradiotherapy,nCRT)後的延期手術可以增加根治切除機會,降低跼部複髮,同時改善患者總體生存率。常規的術前放化療與手術之間的時間間隔為4~6週,延長手術時間間隔可以增加腫瘤退縮的程度,但是超過6~8週也可能會增加手術難度、手術併髮癥髮生率及腫瘤複髮或轉移的風險。迴顧分析相關文獻,從腫瘤緩解率、預後、患病率和死亡率等方麵對nCRT後延期手術時機選擇對預後影響的研究進展進行綜述。
진전기직장암행신보조방화료(neoadjuvant chemoradiotherapy,nCRT)후적연기수술가이증가근치절제궤회,강저국부복발,동시개선환자총체생존솔。상규적술전방화료여수술지간적시간간격위4~6주,연장수술시간간격가이증가종류퇴축적정도,단시초과6~8주야가능회증가수술난도、수술병발증발생솔급종류복발혹전이적풍험。회고분석상관문헌,종종류완해솔、예후、환병솔화사망솔등방면대nCRT후연기수술시궤선택대예후영향적연구진전진행종술。
Neoadjuvant chemoradiotherapy (nCRT) is used to downstage locally advanced rectal cancer before surgery, in order to increase the chance of radical resection, reduce local recurrence, and improve overall survival. Accumulating data suggest that tumor response to nCRT is time dependent. A delay between nCRT and surgery may increase the proportion of patients that achieve a favorable response, and 4-6 weeks are considered to be a universal interval. However, delayed surgery beyond 6-8 weeks may increase the technical dififculty, and the risks of surgical complications and recurrence or metastasis. This article brielfy reviews the relevant literature to evaluate the efifciency and safety of delayed surgery.