中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2015年
8期
629-634
,共6页
王玉洁(综述)%柳光宇(审校)
王玉潔(綜述)%柳光宇(審校)
왕옥길(종술)%류광우(심교)
新辅助化疗%腋窝淋巴结%病理完全缓解%前哨淋巴结活检%淋巴结标记
新輔助化療%腋窩淋巴結%病理完全緩解%前哨淋巴結活檢%淋巴結標記
신보조화료%액와림파결%병리완전완해%전초림파결활검%림파결표기
Neoadjuvant chemotherapy%Axillary lymph nodes%Pathological complete response%Sentinel lymph nodes biopsy%Marking lymph nodes
新辅助化疗或新辅助化疗联合生物靶向治疗日趋成为局部晚期乳腺癌(Ⅱb~Ⅲ)的标准治疗方式,除了能降低原发肿块的临床分期,约有40%的患者能达到腋窝淋巴结的病理完全缓解,从而实现了腋窝淋巴结的降期。而对于经过新辅助化疗或化疗联合靶向治疗后经影像学评估达到腋窝淋巴结临床完全缓解的患者,其腋窝淋巴结缓解情况的预测及新辅助化疗后腋窝前哨淋巴结活检等,仍存在诸多争议,成为临床治疗选择上的难题。本文拟对近年来新辅助化疗后腋窝淋巴结处理的相关研究及临床试验进行分析和解读,并对新近开展的临床研究进行梳理,以期为临床提供更多参考信息。
新輔助化療或新輔助化療聯閤生物靶嚮治療日趨成為跼部晚期乳腺癌(Ⅱb~Ⅲ)的標準治療方式,除瞭能降低原髮腫塊的臨床分期,約有40%的患者能達到腋窩淋巴結的病理完全緩解,從而實現瞭腋窩淋巴結的降期。而對于經過新輔助化療或化療聯閤靶嚮治療後經影像學評估達到腋窩淋巴結臨床完全緩解的患者,其腋窩淋巴結緩解情況的預測及新輔助化療後腋窩前哨淋巴結活檢等,仍存在諸多爭議,成為臨床治療選擇上的難題。本文擬對近年來新輔助化療後腋窩淋巴結處理的相關研究及臨床試驗進行分析和解讀,併對新近開展的臨床研究進行梳理,以期為臨床提供更多參攷信息。
신보조화료혹신보조화료연합생물파향치료일추성위국부만기유선암(Ⅱb~Ⅲ)적표준치료방식,제료능강저원발종괴적림상분기,약유40%적환자능체도액와림파결적병리완전완해,종이실현료액와림파결적강기。이대우경과신보조화료혹화료연합파향치료후경영상학평고체도액와림파결림상완전완해적환자,기액와림파결완해정황적예측급신보조화료후액와전초림파결활검등,잉존재제다쟁의,성위림상치료선택상적난제。본문의대근년래신보조화료후액와림파결처리적상관연구급림상시험진행분석화해독,병대신근개전적림상연구진행소리,이기위림상제공경다삼고신식。
Neoadjuvant chemotherapy or neoadjuvant chemotherapy in combination with targeted therapy has been widely accepted as the standard treatment for locally advanced breast cancer (Ⅱb-Ⅲ). Nearly forty percent of the patients who accepted neoadjuvant chemotherapy achieved pathological complete response of axillary lymph nodes in addition to downstage the primary lesions. However, for patients with clinical complete response of lymph nodes after pre-operative systemic therapy, there are constant controversies regarding the prediction of axillary lymph nodes response and sentinel lymph nodes biopsy after the treatment. Here we design to review the latest studies about how to evaluate the axillary lymph nodes response after neoadjuvant chemotherapy and try to enlighten the treatment choices in clinical practice.