CAJ | 학술논문

目的：探讨胎盘绒毛膜血管瘤的临床病理特点、诊断及鉴别诊断。方法回顾性分析25例胎盘绒毛膜血管瘤的临床病理资料、大体及镜下形态学特点，采用免疫组织化学方法检测肿瘤组织CD34及Ki-67的表达情况。结果25例患者平均年龄29岁，足月产14例，早产10例，胎死宫内1例，19例有妊娠合并症。肿瘤大体表现为凸出于胎盘胎儿面的暗红色、界限较清的结节，直径1～16 cm，切面暗红色，部分可为海绵状血管腔，镜下通常表现为小而密集的毛细血管，部分为扩张的海绵状血管，极少数富于细胞，免疫组织化学染色表达CD34，Ki-67阳性指数＜10％。结论胎盘绒毛膜血管瘤较少见，极少数富于细胞性，易被误诊为恶性，常伴发多种妊娠合并症。
목적：탐토태반융모막혈관류적림상병리특점、진단급감별진단。방법회고성분석25례태반융모막혈관류적림상병리자료、대체급경하형태학특점，채용면역조직화학방법검측종류조직CD34급Ki-67적표체정황。결과25례환자평균년령29세，족월산14례，조산10례，태사궁내1례，19례유임신합병증。종류대체표현위철출우태반태인면적암홍색、계한교청적결절，직경1～16 cm，절면암홍색，부분가위해면상혈관강，경하통상표현위소이밀집적모세혈관，부분위확장적해면상혈관，겁소수부우세포，면역조직화학염색표체CD34，Ki-67양성지수＜10％。결론태반융모막혈관류교소견，겁소수부우세포성，역피오진위악성，상반발다충임신합병증。
Objective To investigate the clinicopathological characteristics , diagnostic criteria and differential diagnosis of placental chorioangioma.Methods Twenty-five cases of placental chorioangioma were analyzed for their clinical data , histomorphology and immumohistochemical staining .Relevant literature was reviewed.Results The average age of the 25 patients was 29 years.Fourteen patients had full-term pregnancy , 10 had preterm labor , and 1 had intrauterine fetal death .Nineteen patients had pregnancy complications.The tumors presented as red or dusty pink nodules with clear borders.The tumor size ranged from 1 to 16 cm.Microscopically , the tumors possessed abundant capillaries or cavernous blood spaces lined by hyperplastic endothelial cells.These cells were positive for CD 34 and Ki-67 index <10%.Conclusions Placental chorioangioma is a rare benign tumor of the placenta , and is associated with various pregnancy complications .Misdiagnosis of cell-rich type tumor should be avoided .