CAJ | 학술논문

目的：观察胎盘多肽注射液联合化疗药物治疗结直肠癌根治术后的临床疗效和安全性。方法选择结直肠癌根治术后化疗患者80例，随机分为研究组和对照组各40例。两组均采用mFOLFOX6方案化疗，研究组在化疗开始时应用胎盘多肽8 ml，静脉滴注，连用14天，所有患者完成6个周期的化疗，观察两组临床疗效和化疗引起的毒副作用。结果①研究组总有效率为45．0％，对照组总有效率为42．5％，两组总有效率比较无统计学差异（P＞0．05）。②两组主要不良反应为恶心、呕吐、腹泻、口腔黏膜炎、外周神经毒性和肝功能损害等。研究组恶心、呕吐、口腔黏膜炎、外周神经毒性发生率显著低于对照组（ P＜0．05）。③治疗前两组白细胞、血小板、血红蛋白水平比较无统计学差异（ P＞0．05），治疗后两组白细胞、血小板、血红蛋白水平显著降低，研究组白细胞水平显著高于对照组（P＜0．05）。结论胎盘多肽注射液联合化疗治疗结直肠癌根治术后患者，可以有效降低化疗的不良反应，提高患者生活质量。
목적：관찰태반다태주사액연합화료약물치료결직장암근치술후적림상료효화안전성。방법선택결직장암근치술후화료환자80례，수궤분위연구조화대조조각40례。량조균채용mFOLFOX6방안화료，연구조재화료개시시응용태반다태8 ml，정맥적주，련용14천，소유환자완성6개주기적화료，관찰량조림상료효화화료인기적독부작용。결과①연구조총유효솔위45．0％，대조조총유효솔위42．5％，량조총유효솔비교무통계학차이（P＞0．05）。②량조주요불량반응위악심、구토、복사、구강점막염、외주신경독성화간공능손해등。연구조악심、구토、구강점막염、외주신경독성발생솔현저저우대조조（ P＜0．05）。③치료전량조백세포、혈소판、혈홍단백수평비교무통계학차이（ P＞0．05），치료후량조백세포、혈소판、혈홍단백수평현저강저，연구조백세포수평현저고우대조조（P＜0．05）。결론태반다태주사액연합화료치료결직장암근치술후환자，가이유효강저화료적불량반응，제고환자생활질량。
Objective To observe the clinical efficacy and safety of placenta polypeptide injection combined with chemo-therapy for colorectal cancer after radical resection.Methods 80 cases of advanced rectal cancer patients treated with chemo-therapy after radical surgery were randomly divided into the study group and the control group,40 cases in each.The 2 groups were given mFOLFOX6 chemotherapy treatment,the study group received additional placenta polypeptide 8ml in chemotherapy, intravenous drip,q.d.for 14d,all patients completed 6 cycles of chemotherapy,clinical curative effects and side effects were ob-served.Results The total effective rate of the study group was 45%,and that of the control group was 42.5%(P>0.05).The main side effects were nausea,vomiting,diarrhea,oral mucositis,alopecia,peripheral neurotoxicity and liver function damage.Nau-sea,vomiting,mucositis,peripheral neurotoxicity in the study group were significantly lower than those of the control group ( P<0.05).WBC,PLT,Hb in the 2 groups before treatment showed no statistical difference (P>0.05),WBC,PLT,Hb decreased significantly in the 2 groups after treatment,and WBC of the study group was significantly higher than that of the control group ( P<0.05).Conclusion Placenta polypeptide injection combined with chemotherapy in the treatment of rectal cancer can reduce the adverse reactions,and improve quality of life of patients.