实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
9期
1410-1412
,共3页
T-VCD方案%VCD方案%老年复发难治性多发性骨髓瘤%临床疗效
T-VCD方案%VCD方案%老年複髮難治性多髮性骨髓瘤%臨床療效
T-VCD방안%VCD방안%노년복발난치성다발성골수류%림상료효
T-VCD%VCD%Elderly patients with relapsed and refractory multiple myeloma%Clinical efficacy
目的：研究T-VCD与VCD治疗老年复发难治性多发性骨髓瘤的临床疗效。方法将收集到的22例老年复发难治性骨髓瘤患者，按照随机数字表法分为T-VCD组和VCD组，每组11例。 T-VCD组给予T-VCD（ T沙利度胺、V长春新碱、C环磷酰胺、D氟美松）联合治疗的方案，VCD组给予VCD（ V长春新碱、C环磷酰胺、D氟美松）治疗方案，观察2组的治疗效果。结果 T-VCD组中完全缓解率为72．7％，部分缓解率为18．2％，稳定及进展率为9．1％；VCD组中完全缓解率为27．3％，部分缓解率为27．3％，稳定及发进展率为45．5％。 T-VCD组的治疗有效率为90．90％，明显高于VCD组的有效率54．54％（P＜0．05）。 T-VCD组和VCD组中血清M蛋白、骨髓浆细胞数与治疗前相比降低，而血红蛋白的水平与治疗前相比升高，2组组内治疗前后对比差异明显（ P＜0．05）。与VCD组相比，T-VCD组指标水平下降或升高更为明显，且治疗后组间对比差异明显（P＜0．05）。结论 T-VCD与VCD治疗老年复发难治性多发性骨髓瘤的效果明显，T-VCD的治疗方案比VCD治疗方案效果更加明显，是临床治疗较好的选择。
目的：研究T-VCD與VCD治療老年複髮難治性多髮性骨髓瘤的臨床療效。方法將收集到的22例老年複髮難治性骨髓瘤患者，按照隨機數字錶法分為T-VCD組和VCD組，每組11例。 T-VCD組給予T-VCD（ T沙利度胺、V長春新堿、C環燐酰胺、D氟美鬆）聯閤治療的方案，VCD組給予VCD（ V長春新堿、C環燐酰胺、D氟美鬆）治療方案，觀察2組的治療效果。結果 T-VCD組中完全緩解率為72．7％，部分緩解率為18．2％，穩定及進展率為9．1％；VCD組中完全緩解率為27．3％，部分緩解率為27．3％，穩定及髮進展率為45．5％。 T-VCD組的治療有效率為90．90％，明顯高于VCD組的有效率54．54％（P＜0．05）。 T-VCD組和VCD組中血清M蛋白、骨髓漿細胞數與治療前相比降低，而血紅蛋白的水平與治療前相比升高，2組組內治療前後對比差異明顯（ P＜0．05）。與VCD組相比，T-VCD組指標水平下降或升高更為明顯，且治療後組間對比差異明顯（P＜0．05）。結論 T-VCD與VCD治療老年複髮難治性多髮性骨髓瘤的效果明顯，T-VCD的治療方案比VCD治療方案效果更加明顯，是臨床治療較好的選擇。
목적：연구T-VCD여VCD치료노년복발난치성다발성골수류적림상료효。방법장수집도적22례노년복발난치성골수류환자，안조수궤수자표법분위T-VCD조화VCD조，매조11례。 T-VCD조급여T-VCD（ T사리도알、V장춘신감、C배린선알、D불미송）연합치료적방안，VCD조급여VCD（ V장춘신감、C배린선알、D불미송）치료방안，관찰2조적치료효과。결과 T-VCD조중완전완해솔위72．7％，부분완해솔위18．2％，은정급진전솔위9．1％；VCD조중완전완해솔위27．3％，부분완해솔위27．3％，은정급발진전솔위45．5％。 T-VCD조적치료유효솔위90．90％，명현고우VCD조적유효솔54．54％（P＜0．05）。 T-VCD조화VCD조중혈청M단백、골수장세포수여치료전상비강저，이혈홍단백적수평여치료전상비승고，2조조내치료전후대비차이명현（ P＜0．05）。여VCD조상비，T-VCD조지표수평하강혹승고경위명현，차치료후조간대비차이명현（P＜0．05）。결론 T-VCD여VCD치료노년복발난치성다발성골수류적효과명현，T-VCD적치료방안비VCD치료방안효과경가명현，시림상치료교호적선택。
Objective To investigate the clinical efficacy of T-VCD and VCD for elderly patients with relapsed and re-fractory multiple myeloma.Methods 22 cases of elderly patients with relapsed and refractory multiple myeloma were divided into the T-VCD group and VCD group according to random number table,each with 11 cases.The T-VCD group were given T-VCD combination therapy program (thalidomide,cyclophosphamide,vincristine and dexamethasone),the VCD group were given VCD ( cyclophosphamide,vincristine and dexamethasone) treatment therapy,the therapeutic effects were observed.Results The com-plete remission of T-VCD group was 72.7%,the partial remission was 18.2%,the stable and progression was 9.1%;while those of the VCD group were 27.3%,27.3%and 45.5%.The effective rate of T-VCD group was 90.90%,which was higher than that of the VCD group(54.54%).Compared with before treatment,the serum M protein,bone marrow plasma cells of the 2 groups were lower after treatment,while the hemoglobin level were higher than before treatment,there had obvious difference(P<0.05). Compared with the VCD group,the index level of the T-VCD group changed more obviously.Conclusion T-VCD and VCD for elderly patients with relapsed and refractory multiple myeloma are effective,while the T-VCD treatment therapy is more effective than VCD treatment therapy,it is a good choice in clinical.
