湖北中医药大学学报
湖北中醫藥大學學報
호북중의약대학학보
JOURNAL OF HUBEI UNIVERSITY OF CHINESE MEDICINE
2015年
4期
8-9
,共2页
膝骨性关节炎%模型%外固定支具
膝骨性關節炎%模型%外固定支具
슬골성관절염%모형%외고정지구
knee osteoarthritis%model%external fixation
目的：探讨新型外固定支具建立兔膝骨性关节炎模型的方法。方法：将10只普通级雄性日本大耳白兔分成2组：传统组使用管型石膏固定方法，新型组使用支具外固定方法，固定6周后，从一般情况、肉眼和HE染色评估两组兔膝关节的形态学和组织学的变化。结果：经过这两种方法造模后，发现兔膝关节的组织形态学效果无明显差别，但是一般情况区别明显。结论：新型外固定支具方法能够成功建立兔膝骨性关节炎模型，具有简单舒适、拆装便利和固定牢靠的优点，而且造模成功率高，死亡率低，具有能够被大批量复制的特点，值得科研推广。
目的：探討新型外固定支具建立兔膝骨性關節炎模型的方法。方法：將10隻普通級雄性日本大耳白兔分成2組：傳統組使用管型石膏固定方法，新型組使用支具外固定方法，固定6週後，從一般情況、肉眼和HE染色評估兩組兔膝關節的形態學和組織學的變化。結果：經過這兩種方法造模後，髮現兔膝關節的組織形態學效果無明顯差彆，但是一般情況區彆明顯。結論：新型外固定支具方法能夠成功建立兔膝骨性關節炎模型，具有簡單舒適、拆裝便利和固定牢靠的優點，而且造模成功率高，死亡率低，具有能夠被大批量複製的特點，值得科研推廣。
목적：탐토신형외고정지구건립토슬골성관절염모형적방법。방법：장10지보통급웅성일본대이백토분성2조：전통조사용관형석고고정방법，신형조사용지구외고정방법，고정6주후，종일반정황、육안화HE염색평고량조토슬관절적형태학화조직학적변화。결과：경과저량충방법조모후，발현토슬관절적조직형태학효과무명현차별，단시일반정황구별명현。결론：신형외고정지구방법능구성공건립토슬골성관절염모형，구유간단서괄、탁장편리화고정뢰고적우점，이차조모성공솔고，사망솔저，구유능구피대비량복제적특점，치득과연추엄。
s:Objective To discuss the method of rabbit model of knee osteoarthritis established with new-type external fixation.Meth-ods 10malebig-earedJapaneserabbitsofcommonlevelweredividedinto2groups:thetraditionalgroupwereimmobilizedwithplaster cast, the new-type group were immobilized with external fixation.After 6 weeks of immobilization, morphological and histological changes of each group were evaluated through general conditions, unaided eyes and HE staining.Results By the two methods of model-making, the founding of study showed that there were no remarkable differences of morphological and histological changes, but the general conditions were significantly different.Conclusions The method of new-type external fixation can successfully induce the rabbit model of knee osteoarthri-tis, has advantages of simplicity, comfort, removable convenience and sturdy fixation, and has higher succeed rate and lower mortality of model, which can be copied on a large scale and more worthy of spreads in the field of scientific research.
