CAJ | 학술논문

目的：观察交泰丸治疗非酒精性脂肪肝（ NAFLD）的疗效。方法将60例NAFLD患者随机分为对照组和治疗组，两组在同等生活行为方式干预基础上分别口服力平之和交泰丸治疗，疗程均为3个月，观察两组的临床疗效及治疗前后的体重、肝功能（ ALT、AST、γ－GT）、血脂（ TC、TG、HDL－C、LDL－C）、游离脂肪酸（ FFA）、内脏脂肪素（Visfatin）、胰岛素抵抗指数（HOMA－RI）、肝脏B超的变化。结果治疗组总有效率优于对照组（P＜0．05）；治疗组体重、血脂、FFA、Visfatin及HOMA－RI均较本组治疗前下降（P＜0．05或P＜0．01），肝脏B超显示脂肪变性减轻（P＜0．05），与对照组比较，差异均有统计学意义（P＜0．05，P ＜0．01）。结论交泰丸治疗NAFLD疗效肯定，能减轻NAFLD患者的体重，改善脂质代谢紊乱，降低血清Visfatin，减轻肝脏脂肪变性，作用机制可能与改善胰岛素抵抗有关。
목적：관찰교태환치료비주정성지방간（ NAFLD）적료효。방법장60례NAFLD환자수궤분위대조조화치료조，량조재동등생활행위방식간예기출상분별구복력평지화교태환치료，료정균위3개월，관찰량조적림상료효급치료전후적체중、간공능（ ALT、AST、γ－GT）、혈지（ TC、TG、HDL－C、LDL－C）、유리지방산（ FFA）、내장지방소（Visfatin）、이도소저항지수（HOMA－RI）、간장B초적변화。결과치료조총유효솔우우대조조（P＜0．05）；치료조체중、혈지、FFA、Visfatin급HOMA－RI균교본조치료전하강（P＜0．05혹P＜0．01），간장B초현시지방변성감경（P＜0．05），여대조조비교，차이균유통계학의의（P＜0．05，P ＜0．01）。결론교태환치료NAFLD료효긍정，능감경NAFLD환자적체중，개선지질대사문란，강저혈청Visfatin，감경간장지방변성，작용궤제가능여개선이도소저항유관。
s:Objective To analysis the clinical efficacy of Jiaotai pill in treatment of nonalcoholic fatty liver disease( NAFLD) .Meth-ods 60patientswithNAFLDwererandomlydividedintotreatmentgroupandthecontrolgroup.Twogroupsweregiventhesamelifeinter-vention, plus lipantyl and Jiaotai pill respectively.Clinicial efficacy body weight, hepatic function, blood lipids includingtotal cholesterol (TC), triglyceride(TG),high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), plasma lev-els of free fatty acid (FFA), homeostasis model assessment-insulin resistance index( HOMA-RI), serum Visfatin and liver ultrasonic were detected before and at the end of the three months’ treatment.Results Total effective rate of treatment group was superior to that of control group(P<0.05).Body weight, blood lipids ,FFA,serum Visfatin and HOMA-RI of treatment group were decreased significantly( P<0.05, P<0.01).Liver ultrasonic of treatment group was also improved significantly( P<0.05).Compared with control group, the differences were statistically significant( P<0.05, P<0.01).Conclusion Jiaotai pill in treatment of NAFLD has significantly clinical ef-ficacy,it is suggested that body weight,disturbances of lipids metabolism and hepatic fattydegeneration were improved.The therapeutic mecha-nism might be related to improving insulin resistance.