CAJ | 학술논문

目的：探讨纳米炭混悬液与美蓝在乳腺癌前哨淋巴结活检中的应用价值和优势。方法收集303例临床腋窝淋巴结阴性且进行了前哨淋巴结活检手术的早中期乳腺癌病例，依据使用纳米炭混悬液或者美蓝作为淋巴结示踪剂分为两组，其中纳米炭组138例，美蓝组165例。手术切除的前哨淋巴结送病理检查。结果纳米炭组检出率为99．3％，美蓝组检出率为93．9％，使用纳米炭混悬液SLN检出率高于使用美蓝者（P＜0．05）。纳米炭组共检出SLN 696枚，平均5．1枚，美蓝组检出SLN 544枚，平均3．5枚（P＝0．000），使用纳米炭混悬液检出的SLN比美蓝要多。使用美蓝时，出现示踪不理想的概率高于纳米炭（P＜0．05）。使用上述两种示踪剂的检出率与患者肿瘤大小、肿瘤部位、术前腋窝淋巴结触诊情况、肿瘤分子分型、年龄、肥胖因素均无关（P均＞0．05）。结论纳米炭混悬液示踪效果好，能检出更多的SLN，SLN检出率更高。
목적：탐토납미탄혼현액여미람재유선암전초림파결활검중적응용개치화우세。방법수집303례림상액와림파결음성차진행료전초림파결활검수술적조중기유선암병례，의거사용납미탄혼현액혹자미람작위림파결시종제분위량조，기중납미탄조138례，미람조165례。수술절제적전초림파결송병리검사。결과납미탄조검출솔위99．3％，미람조검출솔위93．9％，사용납미탄혼현액SLN검출솔고우사용미람자（P＜0．05）。납미탄조공검출SLN 696매，평균5．1매，미람조검출SLN 544매，평균3．5매（P＝0．000），사용납미탄혼현액검출적SLN비미람요다。사용미람시，출현시종불이상적개솔고우납미탄（P＜0．05）。사용상술량충시종제적검출솔여환자종류대소、종류부위、술전액와림파결촉진정황、종류분자분형、년령、비반인소균무관（P균＞0．05）。결론납미탄혼현액시종효과호，능검출경다적SLN，SLN검출솔경고。
Objective To evaluate the efficacy and advantages of carbon nanoparticles suspension ( CNPS) and methyl-ene blue ( MB) as a tracer in sentinel lymph node biopsy ( SLNB) for breast cancer.Methods 303 breast cancer patients who performed sentinel lymph node biopsy were divided into 2 groups according to different lymphatic mapping tracer injected.138 pa-tients injected CNPS, and 165 patients injected MB.SLN received pathological detection.Results The identification rate of CNPS group was 99.3%,which was significantly higher than that of MB group (93.9%,P<0.05) .The average number of senti-nel lymph node ( SLN ) was 5.1 in CNPS group versus 3.5 in MB group (P=0.000).A higher ratio of getting unsatisfied dye-ing results occurred in MB group (P<0.05).The identification rate of the 2 groups were not significantly associated with tumor size,location,preoperative lymph nodes palpation results,tumor molecular subtypes,age or obesity ( all P>0.05) .Conclusion CNPS is an ideal tracer for SLNB,it has higher diagnosis rate and can identify more SLN.