CAJ | 학술논문

目的：探讨大肠癌淋巴结转移与PTEN、COX-2表达的相关性。方法选取手术切除所得100例患者的大肠癌组织和正常大肠组织，采用免疫组化法检测大肠癌组织和正常大肠组织中PTEN、COX-2的表达。统计分析组织来源者淋巴结转移情况并分析大肠癌淋巴结转移与PTEN、COX-2表达的相关性。结果大肠癌组织中PTEN的阳性表达率为52％，显著低于正常大肠组织的100％；而大肠癌组织中COX-2的阳性表达率为92％，显著高于正常大肠组织的6％，差异有统计学意义（P＜0．01）。 PTEN阳性表达患者淋巴结转移发生率明显低于PTEN阴性表达患者，而COX-2阳性表达患者的淋巴结转移发生率则明显高于COX-2阴性表达患者，差异有统计学意义（P＜0．01）。 Spearman关系分析结果显示，大肠癌淋巴结转移与其PTEN的阳性表达率呈负相关（γ＝－0．758，P＜0．05），与其COX-2阳性表达率则呈正相关（γ＝0．792，P＜0．05）。结论大肠癌淋巴结转移与其PTEN的阳性表达率呈负相关，与其COX-2阳性表达率则呈正相关，PTEN的阴性表达和COX-2的阳性表达可预测大肠癌患者淋巴结转移的发生。
목적：탐토대장암림파결전이여PTEN、COX-2표체적상관성。방법선취수술절제소득100례환자적대장암조직화정상대장조직，채용면역조화법검측대장암조직화정상대장조직중PTEN、COX-2적표체。통계분석조직래원자림파결전이정황병분석대장암림파결전이여PTEN、COX-2표체적상관성。결과대장암조직중PTEN적양성표체솔위52％，현저저우정상대장조직적100％；이대장암조직중COX-2적양성표체솔위92％，현저고우정상대장조직적6％，차이유통계학의의（P＜0．01）。 PTEN양성표체환자림파결전이발생솔명현저우PTEN음성표체환자，이COX-2양성표체환자적림파결전이발생솔칙명현고우COX-2음성표체환자，차이유통계학의의（P＜0．01）。 Spearman관계분석결과현시，대장암림파결전이여기PTEN적양성표체솔정부상관（γ＝－0．758，P＜0．05），여기COX-2양성표체솔칙정정상관（γ＝0．792，P＜0．05）。결론대장암림파결전이여기PTEN적양성표체솔정부상관，여기COX-2양성표체솔칙정정상관，PTEN적음성표체화COX-2적양성표체가예측대장암환자림파결전이적발생。
Objective To explore the relationship between lymph node metastasis of colorectal cancer and expression of PTEN and COX-2.Methods Colorectal cancer tissues and normal colon tissues from 100 colorectal cancer patients were select-ed.Immunohistochemical method was used to detect the expression level of PTEN and COX-2 in colorectal cancer tissues and nor-mal colon tissues.Lymph node metastasis of the patients was statistical analyzed and the relationship between PTEN and COX-2 expression and lymph node metastasis of colorectal cancer patients were analyzed.Results The positive expression rate of PTEN in colorectal cancer tissues was 52%,which was significantly less than 100%of the normal colon tissues,and COX-2 positive ex-pression rate of colorectal cancer tissues was 92%,which was significantly higher than 6%of the normal colon tissues,the differ-ence was statistically significant (P<0.01).Lymph node metastasis rate of PTEN positively expressed patients was obviously lower the PTEN negatively expressed patients,while lymph node metastasis rate of patients with COX-2 positive expression was significantly higher than that of COX-2 negatively expressed patients,the difference was statistically significant ( P <0.01). Spearman relationship analysis showed that colorectal cancer lymph node metastasis and positive expression rate of PTEN was neg-atively correlated (γ=-0.758,P<0.05),and it was positively correlated with patients with COX-2 positive expression (γ=0.792,P<0.05).Conclusion Lymph node metastasis of colorectal cancer is negatively correlated with positive expression rate of PTEN,and positively correlated with COX-2 positive expression rate.Negative expression of PTEN and positive expression of COX-2 can predict the occurrence of lymph node metastasis in patients with colorectal cancer.