CAJ | 학술논문

目的：探讨人附睾蛋白4、AFP对卵巢癌的诊断价值。方法选择卵巢癌患者60例（癌变组），同期行手术的良性卵巢肿瘤60例（瘤变组）及健康体检者60例（对照组）；三组空腹抽取静脉血后进行血清甲胎蛋白及人附睾蛋白4含量的检测与阳性评断。结果癌变组的血清甲胎蛋白与人附睾蛋白4含量明显高于其他两组，而瘤变组的血清甲胎蛋白与人附睾蛋白4含量明显高于对照组，差异有统计学意义（P＜0．05）。随着肿瘤恶性程度的增加，血清甲胎蛋白与人附睾蛋白4的阳性率呈增高趋势，差异具有统计学意义（P＜0．05）。联合检测血清甲胎蛋白与人附睾蛋白4对卵巢癌的诊断敏感性为96．7％，特异性为96．7％。 Spearman等级相关分析结果显示：卵巢癌患者中人附睾蛋白4含量与甲胎蛋白含量呈明显正相关性（r＝0．243，P＜0．05）。结论人附睾蛋白4与甲胎蛋白在卵巢肿瘤组织中都呈高表达状况，联合检测对鉴别卵巢肿瘤的良恶性有很好的敏感性与特异性，值得推广应用。
목적：탐토인부고단백4、AFP대란소암적진단개치。방법선택란소암환자60례（암변조），동기행수술적량성란소종류60례（류변조）급건강체검자60례（대조조）；삼조공복추취정맥혈후진행혈청갑태단백급인부고단백4함량적검측여양성평단。결과암변조적혈청갑태단백여인부고단백4함량명현고우기타량조，이류변조적혈청갑태단백여인부고단백4함량명현고우대조조，차이유통계학의의（P＜0．05）。수착종류악성정도적증가，혈청갑태단백여인부고단백4적양성솔정증고추세，차이구유통계학의의（P＜0．05）。연합검측혈청갑태단백여인부고단백4대란소암적진단민감성위96．7％，특이성위96．7％。 Spearman등급상관분석결과현시：란소암환자중인부고단백4함량여갑태단백함량정명현정상관성（r＝0．243，P＜0．05）。결론인부고단백4여갑태단백재란소종류조직중도정고표체상황，연합검측대감별란소종류적량악성유흔호적민감성여특이성，치득추엄응용。
Objective To investigate the value of human epididymis protein 4 and AFP in the diagnosis of ovarian canc-er.Methods 60 patients with ovarian cancer (cancer group), 60 benign ovarian tumors patients(neoplasia group) and 60 healthy subjects ( control group) were selected,and were given the serum alpha-fetoprotein and human epididymis protein 4 con-tents detection and positive judgment.Results The serum alpha-fetoprotein and human epididymis protein 4 contents in the cancer group were significantly higher than those of the other 2 groups,and the serum alpha-fetoprotein and human epididymis protein 4 neoplasia contents in the neoplasia group were significantly higher than those of the control group,there had statistically significant difference (P<0.05).With the increase of the degree of malignancy,the positive rates of serum alpha-fetoprotein and human epididymis protein 4 showed increasing trend,there had statistically significant difference (P<0.05).Sensitivity of serum alpha-fetoprotein and human epididymis protein 4 in the diagnosis of ovarian cancer was 96.7%, specificity was 96.7%. Spearman rank correlation analysis showed that human epididymis protein 4 contents and AFP contents were positively correlated in patients with ovarian cancer (r=0.243,P<0.05).Conclusion The human epididymis protein 4 and alpha-fetoprotein in o-varian tumors tissues have high expression,combined detection in the diagnosis of benign and malignant ovarian tumors has good sensitivity and specificity,it should be widely applied.