CAJ | 학술논문

目的：探讨肿瘤标志物在肺癌患者诊断、预后预测中的临床价值，为临床研究提供参考依据。方法选择不同临床分期的160例肺癌患者，同期选择160例健康志愿者组成健康对照组，应用蛋白芯片技术检测两组患者血清中的的CEA、NSE、CA125、CYFAR21-1、CA153等肿瘤标志物的浓度，分析检测结果。结果 CEA、NSE、CA125、CYFAR21-1、CA153等肿瘤标志物在肺鳞癌组、肺腺癌组与SCLC组的阳性率均高于健康对照组（ P＜0．05）；CEA、CA153以及CA125在肺腺癌组的阳性率显著高于肺鳞癌组和SCLC组（P＜0．05）；NSE和CYFAR21-1在SCLC组的阳性率显著高于肺鳞癌组、肺腺癌组（P＜0．05）；CEA、NSE、CA125、CYFAR21-1、CA153等肿瘤标志物在Ⅰ～Ⅱ期组、Ⅲ期组与Ⅳ期组的阳性率显著高于健康对照组；CA125与CYFAR21-1在Ⅲ期组与Ⅳ期组的阳性率显著高于Ⅰ～Ⅱ期组（P＜0．05）；肿瘤标志物阳性组患者为110例，死亡88例（80．0％），血清肿瘤标志物2项以上阳性组患者45例，死亡43例（95．6％）。50例肿瘤标志物阴性组患者中死亡15例（30．0％），显著低于肿瘤标志物阳性患者和血清肿瘤标志物2项以上阳性组患者的比例（P＜0．05）。结论肿瘤标志物的检测对肺癌有辅助诊断作用，同时对其预后预测有一定的临床指导意义。
목적：탐토종류표지물재폐암환자진단、예후예측중적림상개치，위림상연구제공삼고의거。방법선택불동림상분기적160례폐암환자，동기선택160례건강지원자조성건강대조조，응용단백심편기술검측량조환자혈청중적적CEA、NSE、CA125、CYFAR21-1、CA153등종류표지물적농도，분석검측결과。결과 CEA、NSE、CA125、CYFAR21-1、CA153등종류표지물재폐린암조、폐선암조여SCLC조적양성솔균고우건강대조조（ P＜0．05）；CEA、CA153이급CA125재폐선암조적양성솔현저고우폐린암조화SCLC조（P＜0．05）；NSE화CYFAR21-1재SCLC조적양성솔현저고우폐린암조、폐선암조（P＜0．05）；CEA、NSE、CA125、CYFAR21-1、CA153등종류표지물재Ⅰ～Ⅱ기조、Ⅲ기조여Ⅳ기조적양성솔현저고우건강대조조；CA125여CYFAR21-1재Ⅲ기조여Ⅳ기조적양성솔현저고우Ⅰ～Ⅱ기조（P＜0．05）；종류표지물양성조환자위110례，사망88례（80．0％），혈청종류표지물2항이상양성조환자45례，사망43례（95．6％）。50례종류표지물음성조환자중사망15례（30．0％），현저저우종류표지물양성환자화혈청종류표지물2항이상양성조환자적비례（P＜0．05）。결론종류표지물적검측대폐암유보조진단작용，동시대기예후예측유일정적림상지도의의。
Objective To investigate the clinical value of tumor markers in the treatment and prediction of prognosis of lung cancer,and provide reference for clinical research.Methods 160 cases of lung cancer patients in different clinical stages were selected,and 160 cases of healthy volunteers were the control group,serum protein chip was used to detect the CEA,NSE, CA125,CYFAR21-1,CA153 and other tumor markers concentrations in the 2 groups,test results were analyzed.Results The positive rates of CEA,NSE,CA125,CYFAR21-1,CA153 and other tumor markers in lung squamous cell carcinoma,lung adeno-carcinoma and SCLC group were higher than those of the control group(P<0.05);the positive rates of CEA,CA153 and CA125 in lung adenocarcinoma were significantly higher than those of lung squamous cell carcinoma and SCLC group(P<0.05),The positive rates of NSE and CYFAR21-1 in SCLC were significantly higher than those of lung squamous cell carcinoma and lung ad-enocarcinoma (P<0.05);the positive rates of CEA,NSE,CA125,CYFAR21-1,CA153 and other tumor markers in stage Ⅰ~Ⅱ,ⅢandⅣSCLC were significantly higher than those of the control group;The positive rates of CA125 and CYFAR21-1 in stageⅢandⅣwere significantly higher than that of stageⅠ~Ⅱgroup (P<0.05);tumor marker-positive patients were 110 cases, death 88 cases,the proportion was 80.0%,patients with over 2 positive serum tumor markers were 45 cases,death 43 cases,the proportion was 95.6%.50 cases of patients with negative tumor markers had 15 cases of death,the proportion was 30.0%,which were significantly lower than the proportion of patients with positive tumor markers and patients with over 2 positive serum tumor markers (P<0.05).Conclusion The detection of tumor markers has a supporting role in the diagnosis of lung cancer,and cer-tain clinical significance for prediction of prognosis.