CAJ | 학술논문

目的：观察肾交感神经消融是否可以保护心衰犬左室收缩功能。方法19只比格犬随机分为3组：假手术组（n=6）、对照组（n=7）和消融组（n=6）。假手术组犬装起搏器，但不开启；对照组装好起搏器后开始快速右室起搏3周；消融组先对双侧肾交感神经消融，同时植入起搏器，3d后开启快速右室起搏。左室应变通过超声二维斑点追踪技术来评价。结果3周后，对照组和消融组犬左室舒张末期容积较假手术组大；但是，消融组犬左室射血分数高于对照组（P<0.05）。长径方向、圆周方向和径向方向上左室收缩期应变消融组均高于对照组（P<0.05）。结论肾交感神经消融可以保护心衰犬左室收缩功能。
목적：관찰신교감신경소융시부가이보호심쇠견좌실수축공능。방법19지비격견수궤분위3조：가수술조（n=6）、대조조（n=7）화소융조（n=6）。가수술조견장기박기，단불개계；대조조장호기박기후개시쾌속우실기박3주；소융조선대쌍측신교감신경소융，동시식입기박기，3d후개계쾌속우실기박。좌실응변통과초성이유반점추종기술래평개。결과3주후，대조조화소융조견좌실서장말기용적교가수술조대；단시，소융조견좌실사혈분수고우대조조（P<0.05）。장경방향、원주방향화경향방향상좌실수축기응변소융조균고우대조조（P<0.05）。결론신교감신경소융가이보호심쇠견좌실수축공능。
Objective To investigate whether renal sympathetic nerve ablation can protect the systolic function of left ventricular (LV) during the progression of heart failure (HF). Methods 19 beagle dogs were randomly divided into three groups:sham-operated group (n=6), control group (n=7) and ablation group (n=6). Sham-operated group were implanted with pacemakers without pacing. Control group were implanted with pacemakers and underwent 3 weeks of rapid right ventricular pacing, and ablation group bilateral renal sympathetic nerve ablation first, at the same time implanted with pacemakers. 3 days after the rapid right ventricular pacing. Left ventricular strain were analyzed by two-dimensional speckle traching imaging Re-sults After 3 weeks, all the dogs in the control group and ablation group showed greater LV end-diastolic volume compared with the sham-operated group, however, the dogs in the ablation group had a higher LV ejection fraction (LVEF) than the con-trol group (P<0.05). The LV systolic strains were higher in the ablation group than in the control group (P<0.05) for longitudi-nal, circumferential and radial strain, respectively. Conclusion Renal sympathetic nerve ablation can protect the systolic function of left ventricular during the progression of heart failure in dogs.