CAJ | 학술논문

目的：通过正交试验法优化目标产物2－（5－硝基苯并咪唑基）乙腈合成工艺条件。方法根据3因素4水平正交试验设计，以5－硝基苯并咪唑和氯乙腈为原料，通过亲核取代反应合成目标产物，以反应转化率为指标，优化实验条件。目标化合物通过 IR、1 HNMR 进行结构表征。结果以氢氧化钾为缚酸剂，乙酸乙酯为溶剂，反应时间8h，得到的目标化合物总得率最高（79．9％），且后处理简单。结论通过正交试验法优化2－（5－硝基苯并咪唑基）乙腈的合成，所得产物产率高、纯度好。
목적：통과정교시험법우화목표산물2－（5－초기분병미서기）을정합성공예조건。방법근거3인소4수평정교시험설계，이5－초기분병미서화록을정위원료，통과친핵취대반응합성목표산물，이반응전화솔위지표，우화실험조건。목표화합물통과 IR、1 HNMR 진행결구표정。결과이경양화갑위박산제，을산을지위용제，반응시간8h，득도적목표화합물총득솔최고（79．9％），차후처리간단。결론통과정교시험법우화2－（5－초기분병미서기）을정적합성，소득산물산솔고、순도호。
OBJECTIVE To optimized condition on the synthesis of 2-( 5-nitro-benzimidazole ) acetonitrile by orthogonal experiment.METHODS According to L9 (34 ) orthogonal experiment design,the target product 2-(5-ni-troben-zimidazole) acetonitrile was synthesized from the nucleophilic substitution reaction of 5-nitrobenzimidazole and chloroacetonitrile.Optimized experimental condition base on reaction conversion rate index,and the structure of syn-thetic compound determined by IR、1 H-NMR analysis.RESULTS The target compound had the higher rate (79.9%) with potassium hydroxide as bound acid,ethyl acetate as solvent,the reaction time was 8h,and the post-processing was simple.CONCLUSION The synthesis of target compound 2-(5-nitrobenzimidazole) acetonitrile by orthogonal experiment is high yield and good purity.