CAJ | 학술논문

目的：探讨含大蒜素的五联疗法治疗十二指肠溃疡的临床疗效。方法幽门螺杆菌阳性的十二指肠溃疡患者92例，随机分为治疗组和对照组，各46例，对照组第一周口服艾普拉唑＋枸橼酸铋钾＋替硝唑＋克拉霉素，第二至四周口服艾普拉唑。治疗组在对照组基础上加服大蒜素。观察幽门螺杆菌根除、溃疡愈合及症状改善情况。结果治疗组的根除率高于对照组（ P＜0．05）。两组痊愈率差异无统计学意义（ P＞0．05）；疼痛消失时间差异无统计学意义（P＞0．05）。结论含大蒜素的五联疗法对幽门螺杆菌有较高的根除率，能有效缓解疼痛症状，促进十二指肠溃疡愈合。
목적：탐토함대산소적오련요법치료십이지장궤양적림상료효。방법유문라간균양성적십이지장궤양환자92례，수궤분위치료조화대조조，각46례，대조조제일주구복애보랍서＋구연산필갑＋체초서＋극랍매소，제이지사주구복애보랍서。치료조재대조조기출상가복대산소。관찰유문라간균근제、궤양유합급증상개선정황。결과치료조적근제솔고우대조조（ P＜0．05）。량조전유솔차이무통계학의의（ P＞0．05）；동통소실시간차이무통계학의의（P＞0．05）。결론함대산소적오련요법대유문라간균유교고적근제솔，능유효완해동통증상，촉진십이지장궤양유합。
OBJECTIVE To investigate the clinical efficacy of allicin combined four-medicine therapy in pa-tientswithduodenalulcer.METHODS 92patientswithduodenalulcerandHelicobacterpylori(Hp)infection were randomly divided into 2 groups.Control group was treated by llaprazole tablets+bismuth potassium citrate+cla-rithromycin+tinidazole in frist week,and laprazole tablets in next 2~4 weeks;the treatment group was given allicin on the basis of control.recording the improvement of symptoms and adverse, reaction eradication rates of Hp.RESULTS After 4 weeks,the cure rate of ulcer in the treatment group was higher than control ( P<0.05) .Disappearing time of pain in the treatment group was no obvious difference ( P>0.05 ) .CONCLUSION Allicin combined four-medicine therapy on Hp has a higher eradication rate,high cure rate of duodenal ulcer and pain disap-peared in a short time.