CAJ | 학술논문

研究金针菇发酵液对大鼠动脉血栓的影响及可能机制。三氯化铁诱导大鼠颈动脉血栓模型，观察金针菇发酵液对血栓重量和血管组织形态学改变。检测血浆6-酮-前列腺素E1α（6-keto-PGE1α）、血栓素B2（TXB2）、血管内皮素-1（ET-1）、组织纤溶酶原激活物（t-PA）和纤溶酶原激活物抑制剂（PAI-1）的含量和一氧化氮（NO）水平。与模型组相比，用药组的血栓重量显著降低，血管内的血栓被溶解，血管内膜的损伤较轻。金针菇发酵液不同程度地提高NO、6-keto-PGE1α和t-PA水平，同时减少PAI-1和TXB2的含量，对ET-1水平的的影响并不明显。金针菇发酵液具有溶栓活性，它对血管内皮细胞的保护作用有可能是其溶栓机制之一。
연구금침고발효액대대서동맥혈전적영향급가능궤제。삼록화철유도대서경동맥혈전모형，관찰금침고발효액대혈전중량화혈관조직형태학개변。검측혈장6-동-전렬선소E1α（6-keto-PGE1α）、혈전소B2（TXB2）、혈관내피소-1（ET-1）、조직섬용매원격활물（t-PA）화섬용매원격활물억제제（PAI-1）적함량화일양화담（NO）수평。여모형조상비，용약조적혈전중량현저강저，혈관내적혈전피용해，혈관내막적손상교경。금침고발효액불동정도지제고NO、6-keto-PGE1α화t-PA수평，동시감소PAI-1화TXB2적함량，대ET-1수평적적영향병불명현。금침고발효액구유용전활성，타대혈관내피세포적보호작용유가능시기용전궤제지일。
To study the effect of Flammulina Velutipes fermentation broth on arterial thrombosis in rats and its mechanisms. Animal model was induced by ferric chloride in rats, then the thrombus weight was detected, the morphological changes of vascular tissue were observed, and the levels of 6-keto-PGE1α, TXB2, ET-1, t-PA, PAI-1 and NO in plasma were measured. As compared with the model group, the thrombus weight reduced, the intravascular thrombosis dissolved to some extent, and vascular intimal damage reduced in Flammulina Velutipes fermentation broth group. Flammulina Velutipes fermentation broth increased the levels of NO , 6-keto-PGE1αand t-PA, reduced PAI-1 and TXB2 content. However, there was no significant difference in the ET-1 level. Flammulina Velutipes fermentation broth has the thrombolytic function. The effects may be due to its protective effect on vascular endothelial.